Sulfonated Polyvinyl Acetate Solid Dispersion for Agrochemical Solubility
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Solution Overview
Problem
Existing agrochemicals with poor water solubility are not effectively absorbed or utilized due to their low solubility, despite their pharmacological potential, and existing solid dispersion techniques using polyvinyl alcohol copolymers do not sufficiently enhance water solubility.
Innovation Solution
A composition comprising a poorly water-soluble agrochemical active compound dispersed in a saponification product of polyvinyl acetate with sulfonic acid or sulfonate groups, which improves water solubility by forming an amorphous or semi-amorphous state, and a method involving spray-drying or melt extrusion for production.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If polyvinyl alcohol copolymer is used as a base for solid dispersion, then the chemical can be dispersed in solid media, but the water solubility improvement is insufficient
Solution Approach 1:
The patent modifies the chemical structure of polyvinyl alcohol by introducing sulfonic acid groups or sulfonate groups at specific positions (alpha, beta, or gamma positions relative to the hydroxyl group). This parameter change in the polymer structure dramatically enhances water solubility compared to conventional polyvinyl alcohol copolymers without compromising the solid dispersion capability.
Solution Approach 2:
The invention creates a composite material system where the agrochemical active compound is dispersed within the modified polyvinyl alcohol matrix containing sulfonic acid or sulfonate groups. This composite structure combines the dispersibility of solid media with the enhanced water solubility provided by the charged functional groups, effectively resolving the contradiction between solid dispersion and water solubility enhancement.
2Reliability
If agrochemical active compound with poor water solubility is used, then pharmacological action is excellent, but absorption from roots and leaves is poor
Solution Approach 1:
The modified polyvinyl alcohol acts as an intermediary carrier that bridges the poorly water-soluble agrochemical and the aqueous environment in plants. The sulfonic acid/sulfonate groups on the polymer provide hydrophilicity and charge that facilitate interaction with plant tissues, while the dispersed agrochemical maintains its pharmacological activity. This mediator enables both absorption and retains efficacy.
Solution Approach 2:
By changing the physical state of the agrochemical from pure crystalline form to dispersed amorphous or semi-amorphous state within the polymer matrix, the invention improves bioavailability and absorption. The modified polymer structure parameters (sulfonic acid/sulfonate content, degree of polymerization) are optimized to enhance solubility while maintaining the agrochemical's pharmacological properties.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Significantly enhances the water solubility of poorly soluble agrochemicals, maintaining high solubility levels for an extended period when combined with aromatic sulfonic acid type polymeric surfactants.
Implementation Method 1
wherein the poorly water-soluble agrochemical active compound is dispersed in the solid medium in an amorphous state or in a semi-amorphous state
Implementation Method 2
a step of spray-drying the solution
Implementation Method 3
a step of granulating the mixture by melt extrusion
Data Source
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AI summary
A composition comprising a poorly water-soluble agrochemical active compound and a solid medium comprising a saponification product of polyvinyl acetate comprising at least one selected from the group consisting of a sulfonic acid group and a sulfonate group, wherein the poorly water-soluble agrochemical active compound is dispersed in the solid medium.