Sulfur-Substituted Fused Ring Insecticides for Broad Pest Control
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Solution Overview
Problem
Existing fused heterocyclic compounds exhibit narrow application range and unsatisfactory insecticidal or acaricidal activity, necessitating the development of new compounds with improved biological and environmental characteristics for enhanced pest control.
Innovation Solution
Development of fused heterocyclic compounds with sulfur substituents, specifically compounds of formula (I), through a multi-step synthesis process involving reactions such as refluxing, coupling, and oxidation, to enhance insecticidal and acaricidal efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing fused heterocyclic compounds are used, then some pest control function is achieved, but the application range is narrow and insecticidal activity is unsatisfactory
Solution Approach 1:
The patent modifies the chemical structure of fused heterocyclic compounds by changing parameters such as introducing sulfur-containing substituents at specific positions (R1, R2, or both), varying heteroatom types (N, O, S), and adjusting substituent groups (alkyl, cycloalkyl, aryl, heteroaryl). These parameter changes in molecular structure result in improved insecticidal activity and expanded application range across different pest types while maintaining compatibility with crop plants.
Solution Approach 2:
The patent creates composite heterocyclic structures by combining different heteroatom types (nitrogen, oxygen, sulfur) within the same molecular framework. Examples include compounds with both nitrogen and sulfur atoms in the heterocyclic ring or as substituents, and structures combining multiple heterocyclic rings. This composite approach enhances biological activity and expands the range of effective pest control applications.
2Reliability
If new fused heterocyclic derivatives with sulfur substituents are developed, then insecticidal activity and application range are improved, but synthesis complexity increases
Solution Approach 1:
The patent divides the synthesis of complex fused heterocyclic compounds with sulfur substituents into multiple discrete steps. Each step focuses on introducing specific functional groups or modifying particular positions in the molecular structure. This segmentation allows for systematic development and optimization of synthesis routes, making the complex compound preparation more manageable and reproducible.
Solution Approach 2:
The patent employs intermediary compounds and reagents in the synthesis process. Intermediate heterocyclic compounds with specific substituents serve as precursors to the final target compounds. These intermediaries facilitate the stepwise construction of complex sulfur-containing heterocyclic structures, enabling controlled introduction of sulfur atoms and functional groups at desired positions.
3Reliability
If sulfur-containing substituents are introduced to enhance efficacy, then pest control effectiveness is improved, but manufacturing precision requirements increase
Solution Approach 1:
The patent applies local quality modification by introducing sulfur-containing substituents at specific positions (R1, R2, or both) within the heterocyclic structure. Different positions are selected based on their impact on biological activity. This localized modification approach allows for precise control over which parts of the molecule are modified to achieve desired pest control effectiveness while minimizing unintended consequences.
Solution Approach 2:
The patent systematically varies parameters such as the type of sulfur-containing group (thioether, thiol, sulfone, etc.), the position of sulfur substitution, and the size and nature of attached substituents. These parameter changes enable optimization of pest control effectiveness while establishing clear synthetic targets that can be achieved with controlled precision in the laboratory.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The synthesized compounds demonstrate effective pest control, particularly against arthropods, with broad application range and compatibility with crop plants, even at low concentrations.
Implementation Method 1
reacting the compound of formula (VII) with a base to give the title compound
Data Source
AI summary
A fused ring compound with a sulfur-containing substituent, a preparation method, an insecticide composition, and use are provided. Compared with the prior art, the fused ring compound with a sulfur-containing substituent has good prevention and treatment effect on many kinds of pests at a relatively low test concentration, providing a basis for research and development of new pesticides.