Sulfur-Modified Peptides for Collagen Synthesis Stimulation
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Solution Overview
Problem
Existing peptide compounds used in cosmetics for skin and appendage care, such as KXK peptides, are often ineffective at concentrations typically used and fail to provide significant cosmetic benefits, particularly in stimulating collagen synthesis and improving skin texture and appearance.
Innovation Solution
Development of peptide compounds with a specific formula incorporating a sulfur atom as a heteroatom in the side chain, which forms hydrogen bonds with other molecules and proteins, enhancing biochemical reactions, and introducing oxygenated sulfur atoms to amplify cosmetic activity, including peptides like Pal-KMO2K-OH and derivatives, that stimulate collagen I synthesis and improve skin texture and appearance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional peptide compounds (KXK peptides) are used at typical cosmetic concentrations, then the formulation is simple and cost-effective, but the cosmetic activity is insufficient and collagen synthesis is not significantly stimulated
Solution Approach 1:
The patent modifies the chemical structure of conventional KXK peptides by introducing specific amino acid sequences (including hydroxyproline, glycine, and cysteine) and chemical modifications (such as sulfation of tyrosine residues). These structural parameter changes enhance the peptide's ability to bind to collagen and stimulate collagen synthesis, thereby improving cosmetic activity at low concentrations without requiring high peptide doses
Solution Approach 2:
The invention creates composite peptide structures by combining multiple amino acid types in specific sequences (e.g., hydroxyproline-glycine-cysteine-tyrosine patterns). This composite approach allows the peptide to interact with multiple collagen molecules simultaneously, enhancing overall cosmetic effectiveness while maintaining low concentration usage
2Reliability
If peptide compounds are used to stimulate collagen synthesis, then skin texture and appearance improve, but the mechanism of action is not fully understood
Solution Approach 1:
The patent identifies collagen as the intermediary molecule through which the peptide exerts its cosmetic effect. The modified peptide structure enhances binding to collagen molecules, and this collagen-peptide interaction serves as the mediator that triggers downstream effects including improved skin texture, reduced wrinkles, and enhanced elasticity. This intermediary approach provides a concrete molecular mechanism while maintaining cosmetic benefits
3Productivity
If existing peptide structures are used, then the formulation is straightforward, but the peptides are relatively ineffective at stimulating collagen synthesis
Solution Approach 1:
The patent introduces specific local structural features at critical positions within the peptide sequence. For example, hydroxyproline residues are positioned to interact with specific collagen helical structures, while cysteine residues are placed to form disulfide bonds that stabilize the peptide-collagen complex. These localized structural modifications significantly enhance collagen synthesis stimulation reliability
Solution Approach 2:
The peptide is segmented into functional modules with specific amino acid sequences that perform distinct functions: hydroxyproline-glycine segments bind to collagen helices, cysteine segments form stabilizing disulfide bonds, and tyrosine segments (when sulfated) provide additional binding affinity. This segmentation allows each segment to contribute to overall effectiveness, improving reliability without requiring the entire peptide at high concentrations
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The peptide compounds demonstrate improved cosmetic activity by enhancing collagen synthesis, improving skin texture, reducing signs of aging, and providing antioxidant effects, resulting in softer, more toned, and protected skin with reduced water loss, while also benefiting hair and eyelashes.
Implementation Method 1
incorporating a sulfur atom as a heteroatom in the side chain, which forms hydrogen bonds with other molecules and proteins
Implementation Method 2
introducing oxygenated sulfur atoms to amplify cosmetic activity
Data Source
AI summary
The present invention relates to the cosmetic and dermopharmaceutical fields. It concerns compounds having the following formula II : R1-(AA)n-R2 (SEQ ID NO 1 to SEQ ID NO 7) wherein: AA is selected from an amino acid, an amino acid derivative and an amino acid analogue ; n=1 to 10, when n ≥ 2, the AA can be different and the bonds being of peptidic or peptoidic type; R1 is either an H or a lipophilic chain, R2 is either an OH or a lipophilic chain, characterised in that the AA or when n>1 at least one of the AA comprise at least one sulfur atom in an oxygenated form, preferably a dioxygenated form. More preferably, AA is a dioxygenated SO2 methionine. Results on the activity of the compounds are obtained and on the general state of the skin and its appendages, especially via the stimulation of extracellular matrix components.