Multi-Component Supplement Formulation for Microbiome Stability
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Solution Overview
Problem
There is a need for convenient and stable sources of healthy microbial diversity that can promote gastrointestinal and overall microbiome health, particularly in individuals with compromised microbiomes or low microbial diversity.
Innovation Solution
The combination of prebiotics, probiotics, postbiotics, and bacteriophages in specific ratios and formulations provides a stable source of stomach-resistant microbial diversity, enhancing gastrointestinal and other microbiome health benefits.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If a multi-component composition (prebiotics, probiotics, postbiotics, bacteriophages) is used, then microbial diversity and health benefits are improved, but formulation complexity and manufacturing difficulty increase
Solution Approach 1:
The composition is divided into four distinct functional segments: prebiotics (e.g., inulin, FOS), probiotics (24+ strains including Lactobacillus, Bifidobacterium), postbiotics (metabolites and cell wall components), and bacteriophages (targeted viral preparations). Each segment addresses specific microbiome needs, allowing complex functionality to be achieved through organized modular components rather than a monolithic formulation.
Solution Approach 2:
The invention creates a composite microbial ecosystem by combining four different types of bioactive components that work synergistically. The prebiotics provide substrate for probiotic growth, the probiotics produce postbiotic metabolites, and bacteriophages selectively modulate pathogenic bacteria. This composite approach achieves greater functional diversity than any single component could provide alone.
2Quantity of substance
If multiple probiotic strains (24+ strains) are included, then microbial diversity and health benefits are improved, but stability and shelf-life issues increase
Solution Approach 1:
Different probiotic strains are selected and formulated based on their specific functional qualities and environmental requirements. The formulation includes strains with complementary characteristics (acid tolerance, bile resistance, adhesion properties) to ensure that each strain maintains its viability and function within the multi-strain ecosystem. This localized optimization of strain selection addresses stability concerns while preserving diversity.
Solution Approach 2:
The formulation includes prebiotic substrates and protective matrices that cushion and protect probiotic strains during storage and passage through the gastrointestinal tract. These protective elements are incorporated beforehand to prevent degradation of the diverse probiotic population, ensuring that all 24+ strains remain viable until they reach their target site in the gut.
3Quantity of substance
If high colony forming units (36 billion CFU) are provided, then probiotic efficacy is improved, but manufacturing precision and quality control difficulty increase
Solution Approach 1:
The invention merges multiple probiotic strains into a single integrated formulation that delivers a total of 36 billion CFU across 24 different strains. This consolidation approach simplifies manufacturing and quality control compared to producing and dosing each strain separately, while still achieving the high total CFU count needed for efficacy. The combined formulation ensures consistent delivery of the full probiotic complex in a single dose.
Data Source
AI summary
This application concerns compositions including at least one prebiotic and/or at least one probiotic and/or at least one postbiotic and/or at least one bacteriophage component(s). Also, methods for preparing prebiotic(s)+probiotic(s)+postbiotic(s)+bacteriophage(s) product formulation for animal or human consumption are disclosed, including by ingesting with water and or total composition as a fastmelt, with water, or other liquid in a shaker cup. Further, uses of said composition as a nutritional source or supplement for humans or animal are disclosed.