Nutritional Supplement Upregulating Endogenous Antioxidant Systems
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Solution Overview
Problem
Conventional nutritional supplements do not effectively upregulate endogenous antioxidant systems, relying on exogenous antioxidants that require regular consumption and do not provide long-lasting benefits in increasing endogenous antioxidants, thus failing to address oxidative stress and aging effectively.
Innovation Solution
A nutritional supplement composition comprising an upregulating compound mixture, including alpha lipoic acid, resveratrol, curcumin, EGCG, Olivol®, rutin, and hesperetin, combined with an exogenous antioxidant mixture and a mineral mixture, designed to upregulate endogenous antioxidant systems through mitophagy and oxidative stress reduction, promoting transcription factors like Nrf2 for enhanced antioxidant gene expression.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional nutritional supplements provide exogenous antioxidants, then protection against free radicals is achieved, but the body's endogenous antioxidant systems are not upregulated and benefits are not long-lasting
Solution Approach 1:
The supplement enables the body's own antioxidant systems to serve themselves by upregulating endogenous production of glutathione and other antioxidants through Nrf2 activation, rather than relying continuously on external supplementation. The composition stimulates the body's intrinsic capacity to generate protective agents.
Solution Approach 2:
The supplement performs preliminary action by activating Nrf2 and upregulating endogenous antioxidant enzymes before oxidative damage occurs, creating a proactive defense system that prepares the body's natural protection mechanisms in advance rather than merely reacting to free radical attacks.
2Productivity
If the body relies on exogenous antioxidants, then ongoing protection is maintained through regular consumption, but the system does not develop enhanced endogenous capabilities
Solution Approach 1:
The body is empowered to produce its own antioxidant substances through upregulated endogenous systems, reducing dependence on external supplement intake. The composition triggers the body's self-sufficient antioxidant synthesis pathways.
Solution Approach 2:
The supplement induces parameter changes in the body's biochemical systems by activating transcription factors like Nrf2, which increases the expression and activity of endogenous antioxidant enzymes, thereby changing the quantitative capacity of the body to produce protective substances.
3Reliability
If conventional supplements focus on providing antioxidants directly, then immediate protection is achieved, but the complex endogenous systems are not activated
Solution Approach 1:
The supplement acts as an intermediary by providing compounds that activate the body's own antioxidant systems through signaling pathways involving transcription factors like Nrf2, rather than directly supplying antioxidants. This intermediary approach triggers a cascade of endogenous responses.
Solution Approach 2:
The complex endogenous systems are activated to serve themselves, with the supplement merely initiating the process. Once activated, the body's own regulatory mechanisms sustain and amplify the antioxidant response without requiring continuous external intervention.
Data Source
AI summary
A composition for supporting endogenous systems related to life span, inhibiting mTOR, and reducing damage associated with oxidative phosphorylation. The composition comprises an upregulating compound mixture configured to upregulate an endogenous antioxidant system, an exogenous antioxidant mixture configured to inhibit oxidation of biomolecules by reactive oxygen species, and a mineral mixture configured to provide one or more cofactors to a endogenous antioxidant enzyme. The endogenous antioxidant system includes regulation of mitophagy through mTOR mediated regulation, and a Nrf2 transcription factors that promotes transcription of antioxidant genes.