Surface-Modified Microsphere Microneedles for Sustained Drug Release
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Solution Overview
Problem
Existing microneedles face challenges with reduced residence time in the body and inadequate sustained-release effects, particularly for diseases requiring continuous drug administration.
Innovation Solution
Microneedles comprising surface-modified microspheres with a dimple structure, formed using a solvent evaporation method, which are biodegradable and encapsulate drugs, providing improved residence time and sustained-release effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If soluble microneedles based on biodegradable polymer are used, then drug delivery into skin is achieved, but residence time in body is reduced due to skin elasticity causing active ingredient escape
Solution Approach 1:
The invention employs microspheres with a spherical geometry and specifically introduces surface dimples or irregularities on the microsphere surface. This spherical shape with surface curvature modifications enables the microspheres to better resist skin elasticity forces after microneedle dissolution, preventing active ingredient escape and thereby extending residence time in the body while maintaining reliable sustained-release效果
Solution Approach 2:
The invention modifies physical parameters of the microsphere including surface morphology (adding dimples or irregularities), size distribution, and material composition. These parameter changes enhance the microsphere's mechanical resistance to skin elasticity and control drug release kinetics, achieving both extended residence time and reliable sustained-release effect
2Duration of action of moving object
If conventional smooth microspheres are used, then manufacturing is simpler, but drug residence time and sustained-release effect are insufficient
Solution Approach 1:
The invention incorporates surface modification (dimple formation) into the microsphere manufacturing process itself, rather than as a separate post-processing step. The preliminary action of adding surfactants or modifying emulsion conditions during microsphere formation automatically creates the desired surface dimples, achieving both improved residence time and manufacturing feasibility without significant additional complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The surface-modified microspheres enhance drug residence time in the body, ensuring effective and prolonged drug delivery for conditions like atopic dermatitis and acne.
Implementation Method 1
forming an O/W emulsion by mixing the oil phase with a water phase... and obtaining surface-modified microspheres by evaporating the solvent from the O/W emulsion
Implementation Method 2
The biodegradable microsphere has a predetermined period of degradation and disappearance in the body based on the degradation mechanism and rate of its main component, a biodegradable polymer. The release of the encapsulated drug within the microsphere occurs over a certain period of time depending on the biodegradation rate of the polymer
Data Source
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AI summary
Microneedles comprising surface-modified microspheres which exhibit improved residence time in body and superior sustained-release effect, and are suitable for the treatment of diseases requiring continuous drug administration due, and a method of preparing the same, are disclosed herein. Microneedles comprising surface-modified microspheres containing a drug according to the present invention exhibit improved residence time in the body and an superior sustained-release effects, and are therefore useful for treatment of conditions and diseases requiring continuous drug administration.