Surgical Adhesive for Tissue Compatibility
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Solution Overview
Problem
Existing medical adhesives used in surgical stapling procedures are not adequately compatible with fragile tissues, leading to uneven application and poor performance, particularly in lung tissue, where the tissue may tear due to unprotected staple lines.
Innovation Solution
A medical adhesive comprising carboxyalkyl cellulose, sorbitol, and sulfated glycosaminoglycans, such as chondroitin sulfate, applied to a medical graft material, which is designed to provide a strong and durable bond while being easily removable from surgical stapler arms, maintaining adhesive strength for at least a month and suitable for use in a variety of medical applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing medical adhesives are applied to fragile lung tissue, then the tissue may be secured, but the tissue may tear due to unprotected staple lines and poor adhesive performance
Solution Approach 1:
The adhesive composition is modified by changing its chemical parameters to include carboxyalkyl cellulose (with specific degree of substitution 0.3-1.5) and sulfated glycosaminoglycans, which fundamentally alters the adhesive's properties to be more compatible with fragile lung tissue while maintaining strong bonding capability
Solution Approach 2:
The adhesive uses a composite formulation combining carboxyalkyl cellulose with sulfated glycosaminoglycans (such as chondroitin sulfate), creating a material that leverages the complementary properties of both components to achieve both tissue compatibility and strong adhesive performance
2Ease of manufacture
If adhesive is applied immediately prior to adhesion of bolster material to surgical stapler, then the adhesive can be applied, but additional manipulation is required and application is uneven
Solution Approach 1:
The adhesive is pre-applied to the bolster material during manufacturing rather than being applied immediately before use in the operating room. This preliminary action eliminates the need for additional manipulation steps and ensures uniform application across the entire bolster surface
Solution Approach 2:
The bolster material is provided in a ready-to-use state with the adhesive already integrated or pre-applied, allowing the surgical team to simply attach the bolster to the stapler without requiring separate adhesive application steps
3Duration of action of stationary object
If adhesive strength is maintained for at least a month, then the bond is durable, but the adhesive must remain stable over extended periods
Solution Approach 1:
The adhesive composition parameters are optimized to balance durability and stability, including controlling the degree of substitution of carboxyalkyl cellulose (0.3-1.5) and the concentration of sulfated glycosaminoglycans, which enables the adhesive to maintain both long-term bond strength and compositional stability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive ensures secure attachment of medical graft materials to tissues, maintains performance characteristics over time, and facilitates easy removal from stapler arms, enhancing surgical procedures by preventing tissue tears and improving handling of fragile tissues.
Implementation Method 1
an adhesive on at least a portion of a surface of the medical graft material, wherein the adhesive comprises: carboxymethyl cellulose, chondroitin sulfate, and sorbitol
Data Source
AI summary
The present disclosure provides medical products including an adhesive containing a carboxyalkyl cellulose and sorbitol. Such medical products can find use as a bolster material for use in conjunction with a surgical fastening device such as a stapler. Such adhesives may include advantageous properties such as the ability to retain tack while stored under a peelable cover. Related methods of manufacture and use are also described.