Surgical Mesh Delivery System for Localized Drug Placement
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Solution Overview
Problem
Conventional drug delivery methods face challenges in achieving sustained, localized drug release at the site of disease, leading to systemic toxicity and reduced efficacy due to poor drug solubility, stability, and selectivity, which limits the effectiveness of treatments for malignancies and infections.
Innovation Solution
A surgical mesh delivery system with a cartridge and introducer is used to accurately and easily place a drug-eluting surgical mesh or buttress at the surgical resection margin, utilizing fixation elements and an ergonomic handle to ensure precise placement and reduced systemic toxicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional drug delivery methods are used, then drugs can be administered systemically, but systemic toxicity occurs and therapeutic efficacy is reduced
Solution Approach 1:
The surgical mesh is designed to deliver drugs locally at the surgical site through controlled release mechanisms, creating a high-concentration drug reservoir at the target tissue while minimizing systemic exposure. The mesh structure provides localized drug storage and release capabilities that conventional systemic administration cannot achieve.
Solution Approach 2:
The surgical mesh acts as an intermediary carrier between the drug and the target tissue, facilitating controlled local delivery. The mesh material serves as a drug reservoir and delivery platform that mediates the interaction between the pharmaceutical agent and the surgical site, enabling sustained release while preventing premature systemic distribution.
2Duration of action of moving object
If sustained localized drug release is achieved through implantable reservoirs, then therapeutic efficacy improves, but device complexity and surgical procedure complexity increase
Solution Approach 1:
The drug delivery reservoir is merged with the surgical mesh structure itself, eliminating the need for separate implantable reservoir devices. The mesh incorporates drug-loaded particles or coatings directly into its architecture, combining the structural support function with the drug delivery function in a single integrated component.
Solution Approach 2:
The surgical mesh serves multiple functions simultaneously: it provides structural reinforcement at the surgical site, acts as a drug delivery platform, and facilitates controlled release kinetics. This multi-functionality eliminates the need for separate dedicated drug delivery devices, reducing overall procedural complexity.
3Reliability
If drug concentration is increased to overcome poor solubility and stability, then therapeutic effect improves, but systemic toxicity increases
Solution Approach 1:
The system creates a localized high-concentration drug environment at the surgical site through the mesh reservoir, maintaining therapeutic efficacy without requiring systemic high-dose administration. The concentrated drug is confined to the local tissue environment where it is needed, preventing systemic circulation of high drug levels.
Solution Approach 2:
The drug delivery system changes the spatial distribution parameter of drug concentration, transforming from uniform systemic distribution to highly concentrated local distribution. This parameter change enables maintaining effective drug levels at the target site while reducing overall systemic exposure and associated toxicity.
4Measurement precision
If precise placement of surgical mesh is achieved, then localized drug delivery efficacy improves, but device complexity and placement difficulty increase
Solution Approach 1:
The surgical mesh is pre-loaded with drug-containing particles or coated with drug formulations before surgery. This preliminary preparation ensures that the mesh is ready for immediate deployment at the surgical site without requiring additional steps for drug loading during the procedure, simplifying the surgical process while maintaining precise drug delivery capabilities.
Data Source
AI summary
Embodiments include a surgical implant delivery system for positioning and affixing a surgical implant (e.g., a surgical mesh, a surgical buttress, etc.) covering a surgical margin. The system includes a cartridge releasably holding the surgical implant and a plurality of fixation elements associated with the surgical implant. The system also includes a introducer having an elongate body, a head pivotably coupled to receive the cartridge forming a combined head and cartridge, and a handle including a grip and an in-line trigger. The introducer also includes an actuation mechanism connected with the in-line trigger of the handle configured to affix the surgical implant to the surgical margin using the one or more fixation elements.