Suspo-emulsion Pesticide Formulation Using Lactic Acid Esters
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Solution Overview
Problem
Formulating stable pesticide compositions containing multiple fungicidally active compounds is challenging due to solubility issues, especially when combining high-melting and low-melting actives, as most compounds are sparingly soluble in water, leading to instability and reduced effectiveness over time.
Innovation Solution
A suspo-emulsion composition using lactic acid esters as the organic solvent, where two fungicidally active compounds with melting points below 90°C are dissolved, and a third compound with a melting point above 90°C is present as solid particles, maintaining stability and effectiveness by preventing Ostwald-ripening and ensuring homogeneous distribution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple fungicidally active compounds are combined in a pesticide composition, then broad-spectrum protection is achieved, but formulation stability deteriorates due to solubility issues and Ostwald-ripening
Solution Approach 1:
The patent uses lactic acid esters as an intermediary solvent to dissolve low-melting fungicidally active compounds. This mediator enables the coexistence of multiple compounds with different melting points without causing Ostwald-ripening, thus maintaining formulation stability while achieving broad-spectrum protection through compound combinations.
Solution Approach 2:
The patent changes the physical state parameters of active ingredients by selecting compounds with specific melting point ranges (below 90°C for dissolved compounds, above 90°C for suspended particles). This parameter control allows stable coexistence of multiple compounds in the suspo-emulsion formulation.
2Reliability
If high-melting and low-melting active ingredients are combined, then enhanced fungicidal activity is achieved, but formulation stability deteriorates due to Ostwald-ripening of high-melting actives
Solution Approach 1:
Lactic acid esters serve as a specialized intermediary solvent that selectively dissolves low-melting compounds while leaving high-melting compounds as stable suspended particles. This prevents Ostwald-ripening by maintaining a clear phase boundary between dissolved and suspended components, enabling reliable fungicidal activity from both compound types.
Solution Approach 2:
The patent segments the active ingredients into two distinct functional groups: low-melting compounds (below 90°C) dissolved in lactic acid esters and high-melting compounds (above 90°C) as suspended particles. This segmentation prevents interaction-induced instability while maintaining enhanced fungicidal activity through the synergistic combination of both groups.
3Ease of manufacture
If water-soluble pesticide compounds are used, then ease of formulation is improved, but effectiveness deteriorates because most fungicidally active compounds are sparingly soluble in water
Solution Approach 1:
The patent changes the solubility parameters by introducing lactic acid esters as an organic solvent phase. This allows sparingly water-soluble fungicidally active compounds to be effectively formulated while maintaining their inherent effectiveness, as the lactic acid ester phase provides appropriate solubility without requiring water solubility modification.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves enhanced storage stability and maintains the physical states of active ingredients, allowing for a sprayable liquid formulation with improved fungicidal activity and broad-spectrum protection against phytopathogenic fungi.
Implementation Method 1
two fungicidally active compounds A and B soluted in a lactic acid ester as organic solvent
Implementation Method 2
it may not cause Ostwald-ripening of the high-melting actives
Implementation Method 3
a suspo-emulsion may comprise two fungicides A and B soluted in a selected organic solvent and a third pesticidally active compound C simultaneously present in form of solid particle, all components coexisting in a stable form
Data Source
AI summary
The present invention relates to formulation comprising at least (i) two pesticidal compounds A and B dissolved in a lactic acid ester and wherein a) both A and B have melting points below 900 C b) both A and B are selected from the following list: pyraclos-trobin, metalaxyl, mefenoxam, trifloxystrobin, imazalil, pro-chloraz and ipconazole with the proviso that A is different from B (ii) at least one pesticidal compound C present in solid particles, and having a melting point of 900 C and above, and to their use as seed treatment formulation as well as their use for plant protection, including seed and crop protection.