Sweat Patch Analysis for Non-Invasive Biological Profiling
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Solution Overview
Problem
Existing methods for acquiring biological information from bodily fluids like sweat are limited in their ability to measure a wide range of components and often involve physical or psychological invasiveness, making it difficult to obtain necessary information in a minimally invasive, simple, and rapid manner.
Innovation Solution
A method and system for collecting and analyzing sweat using a patch with a moisture-absorbing portion and adhesive sheet, allowing for the acquisition of biological information through structural equation modeling and machine learning, enabling accurate measurement of components such as amino acids, proteins, and extracellular vesicles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If blood collection is used to measure biological components, then measurement precision is improved, but ease of operation deteriorates due to invasiveness and burden
Solution Approach 1:
The patent uses sweat as an intermediary substance to obtain biological information without directly collecting blood. Sweat contains similar biological components (amino acids, metabolites, hormones) that can reflect internal body state, thus providing an alternative pathway that avoids the invasiveness of blood collection while maintaining measurement value
Solution Approach 2:
The patent replaces the mechanical/invasive blood collection system with a non-invasive sweat collection system using wearable sensors. This substitution eliminates needles and physical intrusion while capturing necessary biological data through sweat analysis
2Ease of operation
If conventional wearable sensors are used to measure sweat components, then ease of operation is improved, but measurement precision deteriorates due to limited component range
Solution Approach 1:
The patent employs mass spectrometry technology that can universally detect and quantify multiple types of biological components (amino acids, metabolites, hormones, lipids) simultaneously in sweat. This multi-functional approach allows a single measurement system to capture comprehensive biological information across diverse molecular classes, overcoming the limitation of sensors that can only measure specific components
Solution Approach 2:
The patent changes the detection parameter from limited electrochemical sensing to broad mass spectral analysis. By measuring mass-to-charge ratio and abundance of ions, the system can identify and quantify numerous different biological molecules in sweat, dramatically expanding the range of measurable components while maintaining ease of operation
3Loss of information
If comprehensive biological analysis is performed, then information provision is improved, but device complexity increases
Solution Approach 1:
The patent segments the analysis system into distinct functional modules: sweat collection module, mass spectrometry measurement module, data processing module, and information provision module. This segmentation allows comprehensive biological analysis to be performed while managing complexity through modular design, where each module handles a specific task in the overall analysis workflow
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables easy, accurate, and comprehensive acquisition of biological information, including skin and muscle conditions, diseases, sleep, and inflammation, with insights into mental and physical health, and provides personalized health recommendations.
Implementation Method 1
a moisture-absorbing portion (30a), capable of absorbing liquid
Implementation Method 2
a moisture-absorbing portion (30a), capable of absorbing liquid
Data Source
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AI summary
The present invention makes it possible to acquire biological information relating to an examination subject more easily or more accurately and to provide the biological information to a user. This living organism examination method for providing biological information relating to an examination subject (1), which is a living organism , by analyzing biological components in the sweat of the examination subject includes: a collection step (S101) for collecting sweat from an examination site of the examination subject (1); a measurement step (S102) for measuring a biological component profile of the sweat collected in the collection step; a biological information acquisition step (S103) for acquiring biological information relating to the examination subject (1) on the basis of the biological component profile measured in the measurement step; and an information provision step (S104) for providing the biological information relating to the examination subject , acquired in the biological information acquisition step, in a predetermined format.