Sweet Corn sh2-i Allele for Seed Vigor and Sugar Retention

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Solution Overview

Problem

Existing sweet corn varieties, particularly those with the shrunken-2 (sh2) gene, suffer from reduced germination and seedling vigor, poor seed quality, and rapid conversion of sugar to starch, leading to diminished shelf life and harvest window, despite having high sugar content.

Innovation Solution

Incorporation of the shrunken-2i (sh2-i) mutant allele, which introduces a single base pair change in the shrunken-2 gene, enhances germination, seedling vigor, and plant growth while maintaining sweetness, but results in accelerated starch synthesis post-peak eating stage.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If the shrunken-2 (sh2) gene is used to increase sugar content, then sweetness is improved, but germination and seedling vigor are reduced

Engineering Contradiction:
Improvesugar contentVSAvoidgermination and seedling vigor
Core Design Contradiction:
Quantity of substanceVSReliability

Solution Approach 1:

The patent applies parameter changes by introducing a single base pair substitution in the sh2 gene that alters the encoded protein's function. This nucleotide-level parameter change modifies the gene's expression or protein activity to simultaneously improve germination vigor while maintaining high sugar content, resolving the contradiction between these two traits.

Inventive Principle:
Principle #35Parameter changes

2Quantity of substance

If the shrunken-2 (sh2) gene is used to increase sugar content, then sweetness is improved, but shelf life is reduced due to rapid starch conversion

Engineering Contradiction:
Improvesugar contentVSAvoidshelf life
Core Design Contradiction:
Quantity of substanceVSDuration of action of stationary object

Solution Approach 1:

The single base pair substitution in the sh2 gene represents a parameter change that modifies the gene's functional properties. This alteration appears to affect the balance between sugar accumulation and starch conversion rates, extending the period during which sweetness is maintained while reducing the rate of starch accumulation that leads to toughening.

Inventive Principle:
Principle #35Parameter changes

3Reliability

If the shrunken-2i (sh2-i) mutant allele is used to improve germination and seedling vigor, then agronomic characteristics are improved, but starch synthesis is accelerated post-peak eating stage

Engineering Contradiction:
Improvegermination and seedling vigorVSAvoidshelf life
Core Design Contradiction:
ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The sh2-i allele appears to provide preliminary action by enhancing germination and seedling vigor early in development. This early benefit is achieved through modified gene function that promotes robust growth, while the trade-off of accelerated starch synthesis occurs only after the peak eating stage, when the crop has already established its consumer quality.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentEP2464213B1Methods for enhancing the production and consumer traits of plants
Publication Date: 2025.10.22 SYNGENTA CROP PROTECITON AG
  • EP2464213B1 patent drawingFigure 1
  • EP2464213B1 patent drawingFigure 2
  • EP2464213B1 patent drawingFigure 3

AI summary

The invention provides methods for producing plants, plant materials and seeds that have multiple desirable attributes for consumers of these products, as well as for commercial plant growers, and to improved plants, plant materials and seeds that are produced by these methods. These inventive methods provide hybrid plants, plant materials and seeds having the mutant shrunken-2i (sh2-i) allele incorporated into their genomes, preferably sequentially along with one or more other mutant alleles, such as the sugary- 1 (su1), sugary enhancer- 1 (se1) and/or shrunken-2 (sh2) alleles, and that have multiple beneficial traits, including an extended sugar retention ability at the post prime eating stage and a significantly enhanced vigor and fitness to the plant, plant material and / or seed during seed germination, seedling emergence from soil, and plant development.