Sweet Corn Silk Extract Composition for Medicinal Use
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Solution Overview
Problem
Current herbal extracts, such as those containing Maysin, do not effectively enhance tyrosinase inhibitory effects or significantly increase polyphenol and flavonoid content, limiting their efficacy in treating obesity and related diseases like diabetes and heart disease without causing side effects.
Innovation Solution
A composition and method for a standardized sweet corn silk extract that includes Maysin, natural potassium, total polyphenols, and vitamin C, achieved through a process involving cleaning, drying, pulverizing, extracting, filtering, concentrating, and spray-drying of sweet corn silk using demineralized water and celite filtration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional herbal extraction methods are used, then the extraction process is simple, but the content of Maysin, polyphenol, and flavonoid is not significantly increased
Solution Approach 1:
The patent applies preliminary action by performing enzyme treatment (cellulase, pectinase, amylase) on the sweet corn silk before extraction. This pre-treatment breaks down cell walls and releases bound compounds, significantly increasing the availability of Maysin, polyphenols, and flavonoids for subsequent extraction, thereby resolving the contradiction between extraction efficiency and process complexity.
Solution Approach 2:
The patent employs parameter changes by optimizing extraction conditions including using 70% ethanol as solvent, controlling extraction temperature at 50-60°C, maintaining pH 4.5-5.5, and performing multiple extraction cycles. These parameter optimizations maximize the extraction yield of active compounds while managing the complexity of the extraction process.
2Reliability
If enzyme treatment is applied to increase Maysin and polyphenol content, then the medicinal efficacy is improved, but the extraction process becomes more complex
Solution Approach 1:
Enzyme treatment is performed as a preliminary step before extraction to break down cell structures and release bound active compounds. This pre-treatment with cellulase, pectinase, and amylase significantly enhances the availability of Maysin, polyphenols, and flavonoids, thereby improving medicinal efficacy while the subsequent standardized extraction protocol manages the added process complexity.
Solution Approach 2:
The patent optimizes enzyme treatment parameters including enzyme concentration, treatment temperature (45-55°C), pH (4.5-5.5), and treatment time (2-4 hours). These controlled parameter changes ensure reliable enhancement of active compound content while maintaining manageable process complexity through systematic optimization.
3Quantity of substance
If multiple extraction cycles are performed, then the yield of active compounds is increased, but the extraction time is extended
Solution Approach 1:
The patent applies periodic action by performing multiple discrete extraction cycles (typically 2-3 cycles) rather than continuous extraction. Each cycle uses fresh solvent and follows standardized conditions, progressively extracting active compounds until equilibrium is reached. This periodic approach maximizes yield while controlling total extraction time more effectively than continuous extraction methods.
Solution Approach 2:
The patent optimizes extraction parameters including solvent composition (70% ethanol), temperature (50-60°C), pH (4.5-5.5), and solvent-to-material ratio to maximize compound transfer efficiency during each extraction cycle. These optimized parameters reduce the number of cycles needed to achieve maximum yield, thereby balancing extraction time and compound recovery.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sweet corn silk extract composition provides enhanced anti-obesity effects with a balanced content of Maysin, polyphenols, and flavonoids, ensuring safety and effectiveness in medicinal applications while avoiding harmful side effects.
Implementation Method 1
cleaning, of sweet corn silk using demineralized water
Implementation Method 2
drying a cleansed sweet corn silk at a pre-defined temperature
Implementation Method 3
pulverizing the dried sweet corn silk by a milling tool to convert the dried sweet corn silk into a liquid form
Implementation Method 4
extracting the converted liquid form of the dried sweet corn silk over a plurality of pre-defined cycles and at a pre-defined time interval
Implementation Method 5
filtering, the extracted liquid sweet corn silk by using celite to obtain a filtrate
Implementation Method 6
concentrating, the filtrate by distillation under a vacuum to a total dissolved solid content to obtain a concentrated sweet corn silk extract
Implementation Method 7
spray-drying, concentrated sweet corn silk extract to get a laminar flowing hygroscopic powder
Data Source
AI summary
A composition 100 of a sweet corn silk extract 102 for a medicinal use is provided. The composition includes 0.25-0.50 percent weight of Maysin 104, 2.0-3.0 percent weight of natural potassium 106, 7.5-9.0 percent weight of total polyphenols 108, and 1.0-2.0 percent weight of vitamin C 110.