Sweetener Composition Using Enzymatic Epimerization

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Solution Overview

Problem

Fructose/glucose liquid sugar used as a sweetener in the food industry differs in sweetness and taste from sucrose, and its consumption is linked to lifestyle-related diseases such as obesity.

Innovation Solution

A sweetener composition comprising D-glucose, D-fructose, and D-psicose at specific ratios, produced through the action of isomerase and epimerase on glucose liquid sugar, which mimics the sweetness and taste of sucrose and offers obesity-preventing properties.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If isomerized sugar (glucose-fructose liquid sugar) is used as a sweetener, then production cost is reduced and sweetness is provided, but the degree and quality of sweetness differs from sucrose and lifestyle-related diseases occur

Engineering Contradiction:
Improveproduction costVSAvoidsweetness quality similarity to sucrose
Core Design Contradiction:
Ease of manufactureVSManufacturing precision

Solution Approach 1:

The patent changes the compositional parameters of the sweetener by introducing D-psicose and adjusting the ratio of D-fructose to D-glucose. Specifically, it sets D-fructose at 30-80 parts by weight, D-glucose at 10-60 parts by weight, and D-psicose at 5-20 parts by weight, which fundamentally alters the sweetness profile to match sucrose while maintaining cost-effectiveness

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite sweetener material combining four different sugars (D-fructose, D-glucose, D-psicose, and optionally D-galactose) in specific proportions. This composite approach allows the mixture to achieve sweetness characteristics similar to sucrose while incorporating D-psicose to prevent lifestyle-related diseases, thus resolving both the cost and quality issues

Inventive Principle:
Principle #40Composite materials

2Quantity of substance

If D-psicose is produced from D-fructose through separate processes, then D-psicose is obtained, but production costs increase due to multiple processing steps

Engineering Contradiction:
ImproveD-psicose contentVSAvoidproduction process complexity
Core Design Contradiction:
Quantity of substanceVSDevice complexity

Solution Approach 1:

The patent merges the D-psicose production step with the existing glucose-fructose liquid sugar production process. By adding D-psicose (produced from D-fructose) to the liquid sugar mixture in a single formulation step rather than requiring separate production lines, the patent achieves the desired D-psicose content while minimizing process complexity and additional costs

Inventive Principle:
Principle #5Merging (Combining)

3Object-affected harmful factors

If D-psicose is used to prevent lifestyle-related diseases, then health benefits are achieved, but the sweetness and taste profile differs from sucrose

Engineering Contradiction:
Improveobesity preventionVSAvoidsweetness quality similarity to sucrose
Core Design Contradiction:
Object-affected harmful factorsVSManufacturing precision

Solution Approach 1:

The patent optimizes the concentration parameter of D-psicose (5-20 parts by weight) and adjusts the ratios of D-fructose and D-glucose to compensate for any taste differences. This parameter optimization ensures that D-psicose provides sufficient health benefits while the overall mixture maintains sweetness quality similar to sucrose

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent uses a composite material approach where D-psicose is combined with D-fructose, D-glucose, and optionally D-galactose in specific proportions. This composite formulation allows the beneficial effects of D-psicose to be preserved while the combination of multiple sugars creates a balanced sweetness profile that mimics sucrose, thus resolving both the health benefit and taste quality requirements

Inventive Principle:
Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The sweetener composition achieves a sweetness and taste similar to sucrose while effectively preventing obesity and other lifestyle-related diseases by adjusting the ratios of D-fructose and D-psicose in the mixture.

Implementation Method 1

Isomerization of glucose by glucose isomerase to fructose is an equilibrium reaction

Methodology Applied
Scientific EffectEnzymatic isomerization: Enzyme

Implementation Method 2

D-psicose is produced from D-fructose by the action of D-ketohexose 3-epimerase

Methodology Applied
Scientific EffectEnzymatic epimerization: Enzyme

Data Source

PatentEP2156751B8Novel sweetener having sugar-like taste and production method and use of the same
Publication Date: 2018.11.14 MATSUTANI CHEM IND CO LTD

AI summary

Problem: To develop a method for producing a novel sweetener containing glucose, fructose, and psicose, which is produced from glucose liquid sugar using an isomerase and an epimerase; use of the novel sweetener as a food or drink material; and a novel sweetener capable of preventing obesity caused by the intake thereof. Means of Resolution: An isomerase and an epimerase are allowed to act on glucose liquid sugar produced in a glucose liquid sugar production plant to thereby produce D-psicose, thereby providing a novel sweetener (product) that maintains the degree and quality of sweetness of a glucose-fructose mixed solution and never causes obesity, a method for producing the same, and use of the same.