Swim Bladder Valve Material for Anti-Calcification
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Solution Overview
Problem
Conventional biological heart valves derived from bovine pericardia suffer from serious calcification issues, leading to poor durability and a limited lifetime of about 10-15 years, necessitating long-term anticoagulation therapy and posing risks of thrombosis and anticoagulation complications.
Innovation Solution
A swim bladder derived biological valve material is prepared by decellularization and cross-linking with a polyphenol compound, such as flavonoids or glutaraldehyde, to maintain mechanical properties and reduce calcification, using a method that includes decellularization, cross-linking, and optional irradiation for sterilization.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional biological valves are made from bovine pericardia, then the valves can be used without long-term anticoagulation therapy, but the valves suffer from serious calcification and have limited lifetime of 10-15 years
Solution Approach 1:
The patent applies parameter changes by modifying the chemical composition and structure of the biological valve material through cross-linking treatment. The cross-linking process alters the physical and chemical parameters of the bovine pericardia, creating a more stable material that resists calcification and degradation, thereby extending valve lifetime while maintaining reliability
Solution Approach 2:
The patent creates a composite material structure by combining bovine pericardia with cross-linking agents. This composite approach integrates the biological properties of the pericardia with the stabilizing effects of cross-linking chemistry, producing a material that simultaneously achieves excellent anti-calcification performance and extended durability
2Duration of action of stationary object
If mechanical valve replacement is used, then the valves have durable structure, but patients require long-term anticoagulation therapy with high risks of thrombosis and complications
Solution Approach 1:
The patent modifies the surface properties and mechanical characteristics of the biological valve material through cross-linking, achieving durability comparable to mechanical valves. The cross-linking process optimizes parameters such as tensile strength, elasticity, and surface morphology to reduce thrombogenicity while maintaining long-term durability
Solution Approach 2:
The patent transforms biological valves from short-lived implants to long-lasting durable substitutes by applying cross-linking technology. This extends the functional lifetime of biological valves to match or exceed mechanical valves, eliminating the need for anticoagulation therapy while achieving comparable durability
3Reliability
If swim bladder material is used instead of bovine pericardia, then the material shows superior anti-calcification performance, but additional processing steps are required
Solution Approach 1:
The patent applies parameter changes by optimizing the cross-linking conditions for swim bladder material, including concentration, temperature, and time parameters. This standardization of processing parameters simplifies the additional steps required while maximizing the anti-calcification benefits of swim bladder-derived materials
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The swim bladder derived biological valve material exhibits superior anti-calcification performance and mechanical stability, comparable to bovine pericardial materials, extending the valve's lifespan and reducing immunogenicity and thrombosis risks.
Implementation Method 1
cross-linking the decellularized swim bladder with a cross-linking agent
Implementation Method 2
the cross-linking compound includes a polyphenol compound
Data Source
AI summary
The present application discloses a biological valve material which is a swim bladder derived biological valve material. The present application also discloses a method for preparing the biological valve material, includes: decellularizing a raw swim bladder; and cross-linking the decellularized swim bladder with a cross-linking agent. The present application also discloses use of the biological valve material, wherein the biological valve material is used for preparing one or more of a biological heart valve, a biological patch, and an artificial blood vessel. The present application also discloses a cross-linking agent for a bio-based material, including a cross-linking compound and an organic solvent. The cross-linking compound includes a polyphenol compound. The present application also discloses use of the cross-linking agent, wherein the cross-linking agent is used to cross-link the bio-based material after the decellularization treatment.