Synbiotic Composition for Gut Flora Balance and Immunity
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for regulating gut flora to enhance immunity and treat diseases are inadequate in effectively promoting the balance of beneficial bacteria and reducing pathogenic bacteria, particularly in the context of respiratory infections such as COVID-19.
Innovation Solution
A probiotic composition comprising Bifidobacterium bifidum, Bifidobacterium longum, and Bifidobacterium adolescentis, combined with prebiotics like xylooligosaccharide, galactooligosaccharide, and corn dietary fiber, to create a synbiotic formulation that promotes the growth of beneficial bacteria and balances gut microecology.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If probiotics and prebiotics are used separately, then some beneficial effects are achieved, but the effectiveness in promoting gut flora balance and immunity enhancement is insufficient
Solution Approach 1:
The patent combines probiotics (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium adolescentis) and prebiotics (xylooligosaccharide, galactooligosaccharide, corn dietary fiber) into a single synbiotic composition. This merging allows the probiotics and prebiotics to work synergistically, where the prebiotics serve as food sources for the probiotics, enhancing their survival and effectiveness in the gut, thereby resolving the insufficiency of separate administration
2Quantity of substance
If conventional probiotic compositions are used, then general gut health is improved, but the specific abundance of desirable bacterial species is not sufficiently increased
Solution Approach 1:
The patent specifies particular strains of Bifidobacterium (bifidum, longum, adolescentis) and particular prebiotics (xylooligosaccharide, galactooligosaccharide, corn dietary fiber) in defined ratios rather than using generic probiotic mixtures. This local quality approach targets specific desirable bacterial species that are particularly beneficial for respiratory infection treatment, thereby increasing their abundance more effectively than conventional broad-spectrum probiotic compositions
3Object-affected harmful factors
If gut flora regulation is attempted with single-component formulations, then simplicity is maintained, but the ability to reduce pathogenic bacteria and enhance immunity is inadequate
Solution Approach 1:
The patent creates a composite synbiotic formulation integrating three specific probiotic strains and three specific prebiotic components in optimized ratios. This composite structure leverages the synergistic effects between probiotics and prebiotics, where prebiotics selectively nourish beneficial bacteria while inhibiting pathogenic bacteria growth, achieving superior pathogen reduction and immunity enhancement compared to single-component formulations despite the increased compositional complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The synbiotic composition significantly increases the abundance of desirable bacterial species, reduces undesirable bacteria, alleviates clinical symptoms, and enhances immune response in COVID-19 patients, improving treatment outcomes and gut health.
Implementation Method 1
probiotics refer to one class of beneficial active microorganisms to a host that colonize in humans to alter the composition of the flora in a certain site of the host
Implementation Method 2
prebiotics should be largely undigested and fermented by gut flora when they pass through the upper digestive tract
Implementation Method 3
prebiotics should be largely undigested and fermented by gut flora when they pass through the upper digestive tract
Implementation Method 4
prebiotics can selectively promote the metabolism and proliferation of probiotics in the body
Implementation Method 5
Probiotics can promote nutrient absorption and maintain the health of the intestine by regulating the immune function of the host mucosa and the system
Data Source
AI summary
A probiotic composition comprising Bifidobacterium bifidum and Bifidobacterium longum, and may further comprising Bifidobacterium adolescentis and Lactobacillus rhamnosus is provided. A prebiotic composition comprising xylooligosaccharide, galactooligosaccharide, and corn dietary fiber, and a dietary composition comprising the probiotic composition and the prebiotic composition are provided. Use of the foregoing compositions in the preparation of a dietary product or a drug for assisting in preventing and/or treating a pathogen infection of an individual, enhancing the therapeutic effect of a pathogen infection of an individual, improving the immunity of an individual, or balancing the gut microecology of an individual is provided. The foregoing compositions can be used in patients suffering from COVID-19.