Synbiotic Composition for Gut Microbiota Modulation

The patent combines multiple probiotic strains (Lacticaseibacillus rhamnosus, Ligilactobacillus salivarius, Bifidobacterium breve, and Bifidobacterium lactis) with prebiotic compounds (inulin and fructooligosaccharides) into a synbiotic composition. This merging of probiotics and prebiotics creates a synergistic effect that enhances the modulation of gut microbiota function and extends health benefits across multiple organ systems, resolving the contradiction between reliability of microbiota modulation and versatility across organ systems.

The synbiotic composition functions as a composite biological product integrating different microbial strains with specific prebiotic compounds. Each component contributes distinct functional properties: Lacticaseibacillus rhamnosus supports immune function, Ligilactobacillus salivarius promotes gut barrier integrity, Bifidobacterium breve and Bifidobacterium lactis diversify microbiota. The prebiotic compounds serve as selective substrates that stimulate beneficial bacteria. This composite structure enables simultaneous modulation of gut microbiota and impact on multiple organ systems including immune, gastrointestinal, and metabolic systems.

The synbiotic composition is segmented into distinct functional modules: four specific probiotic strains each targeting different physiological functions, and two prebiotic compounds providing selective substrates. This segmentation allows for systematic design where each component has a defined role, making the complex composition manageable and easier to formulate while maintaining broad health benefits across organ systems.

The synbiotic composition achieves multi-functionality by selecting microbial strains and prebiotic compounds that simultaneously serve multiple purposes. For example, Bifidobacterium breve and Bifidobacterium lactis not only diversify gut microbiota but also produce short-chain fatty acids that benefit intestinal health, immune function, and metabolic regulation. The prebiotic compounds inulin and fructooligosaccharides serve as both bacterial substrates and prebiotic agents that promote beneficial microbiota growth. This universal design reduces the need for separate formulations for different organ systems.