Synbiotic Gut Health Composition for Barrier Support and Hydration

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Solution Overview

Problem

Existing compositions fail to effectively address the disruption of gut flora balance and intestinal barrier integrity, leading to digestive issues, chronic inflammation, and metabolic disorders, despite the availability of prebiotic and probiotic supplements.

Innovation Solution

A composition comprising Saccharomyces boulardii, multiple Lactobacillus strains, hyaluronic acid, and soluble fibers, optimized to strengthen the intestinal barrier and improve hydration, promoting a balanced gut microbiome and immune function.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If prebiotic and probiotic supplements are used, then gut flora balance can be improved, but intestinal barrier integrity and hydration are not sufficiently addressed

Engineering Contradiction:

Improvegut flora balanceVSAvoidintestinal barrier integrity

Core Design Contradiction:

Stability of the object's compositionVSReliability

Solution Approach 1:

The patent combines multiple functional components into a single composition: probiotics (Lactobacillus and Bifidobacterium strains), prebiotics (inulin and FOS), hyaluronic acid for barrier support, and soluble fibers. This merging approach allows simultaneous improvement of gut flora balance, intestinal barrier integrity, and hydration in one formulation, resolving the contradiction between flora balance and barrier reliability.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention uses a composite formulation containing five distinct ingredient categories that work synergistically. Each component targets specific aspects of intestinal health: probiotics for flora balance, prebiotics for probiotic growth, hyaluronic acid for barrier strength and hydration, and soluble fibers for overall gut health. This composite approach ensures multiple functions are achieved without compromising any single aspect.

Inventive Principle:

Principle #40Composite materials

2Object-affected harmful factors

If conventional probiotic supplements are used, then harmful bacteria can be suppressed, but intestinal wall hydration and barrier function are not improved

Engineering Contradiction:

Improveharmful bacteria suppressionVSAvoidintestinal wall hydration

Core Design Contradiction:

Object-affected harmful factorsVSQuantity of substance

Solution Approach 1:

The patent merges probiotics (for harmful bacteria suppression) with hyaluronic acid (for intestinal wall hydration and barrier function) and soluble fibers (for additional hydration and gut health) into a single composition. This combination ensures that while probiotics suppress harmful bacteria, hyaluronic acid simultaneously improves intestinal wall hydration and strengthens the barrier, resolving the contradiction between pathogen suppression and hydration.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

Hyaluronic acid acts as an intermediary substance that bridges the gap between probiotic action and barrier function. It provides direct hydration to the intestinal wall and supports barrier integrity, while also creating a favorable environment for probiotic colonization and activity. This intermediary role allows the composition to achieve both harmful bacteria suppression and improved hydration simultaneously.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition enhances microbial growth, shifts pathogenic microbes to probiotic microbes, and improves digestive comfort, immune function, and overall well-being by maintaining a healthy gut flora and intestinal barrier.

Implementation Method 1

the addition of hyaluronic acid and soluble fibers not only provides for the strengthening of the intestinal barrier and the optimization of the hydration of the intestinal wall

Methodology Applied

Scientific EffectHydration:

Implementation Method 2

The composition exhibits improved microbial growth compared to the hyaluronic acid and fiber-free conditions. The addition of hyaluronic acid with soluble fibers such as beta-glucans, Inavea Baobab, acacia, and artichoke in the composition improves the growth of Lactobacillus and Saccharomyces.

Methodology Applied

Scientific EffectMicrobial growth:

Implementation Method 3

the hyaluronic acid and soluble fibers cause a shift from pathogenic microbes to probiotic microbes in the intestine

Methodology Applied

Scientific EffectMicrobial population shift:

Data Source

PatentEP4681553A1Composition for use in supporting and/or improving intestinal health and intestinal flora

Publication Date: 2026.01.21 VENTRIBIO BV

Figure 1~2

AI summary

The present invention relates to a composition for use in supporting and/or improving gut health and gut flora, wherein a recommended daily dose of the composition comprises at least a probiotic component comprising Saccharomyces boulardii, and at least three Lactobacillus strains, and a prebiotic component comprising at least two different sources of soluble fibers, wherein the composition further comprises hyaluronic acid and/or a salt thereof.