Synbiotic Mixture Oligosaccharide Composition for Infant Formula
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current probiotic and prebiotic mixtures in infant formulas do not effectively enhance the efficiency and efficacy of probiotic bacteria, particularly in promoting a healthy gut microbiota and preventing pathogenic infections.
Innovation Solution
A prebiotic mixture comprising 5-70 wt % of N-acetylated oligosaccharides, 20-95 wt % of neutral oligosaccharides, and 2-50 wt % of sialylated oligosaccharides, combined with probiotic bacterial strains, is used to enhance the beneficial effects of probiotics, specifically designed for infant formulas to promote a bifidogenic intestinal microbiota and treat gastrointestinal and respiratory tract infections.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional probiotic and prebiotic mixtures are used in infant formulas, then the probiotic bacteria can be administered, but the efficiency and efficacy of probiotics in promoting healthy gut microbiota and preventing pathogenic infections is not enhanced
Solution Approach 1:
The patent combines multiple types of oligosaccharides (N-acetylated, neutral, and sialylated) with probiotic bacteria to create a composite synbiotic preparation. This composite approach enhances the efficacy of probiotics by providing a synergistic effect where the prebiotic oligosaccharides selectively stimulate the growth and activity of beneficial bacteria in the gut, thereby improving both reliability and efficiency of probiotic action
Solution Approach 2:
The patent specifies precise compositional parameters for the oligosaccharide mixture, including weight percentage ranges for each type of oligosaccharide (N-acetylated: 5-70%, neutral: 20-95%, sialylated: 2-50%). By optimizing these parameters, the preparation maximizes the enhancement of probiotic efficiency and efficacy in promoting healthy gut microbiota
2Ease of manufacture
If a simple prebiotic mixture is used, then the preparation is easy to manufacture, but it does not provide synergistic enhancement of anti-pathogenic and immunomodulatory properties
Solution Approach 1:
The patent creates a composite prebiotic mixture comprising three distinct classes of oligosaccharides with specific compositional ratios. This composite structure provides synergistic therapeutic effects including enhanced anti-pathogenic and immunomodulatory properties, while still maintaining relative ease of manufacture through defined composition ranges
Solution Approach 2:
The oligosaccharide mixture serves multiple functions simultaneously: it acts as a prebiotic substrate, enhances probiotic efficacy, provides anti-pathogenic effects, and delivers immunomodulatory benefits. This multi-functionality achieves superior therapeutic effects without significantly complicating the manufacturing process
Data Source
AI summary
This invention relates to a preparation comprising a probiotic bacterial strain and a prebiotic mixture comprising 5-70 wt % of at least one N-acetylated oligosaccharide selected from the group consisting of Ga1NAcα1-3Ga1β1-4G1c, Ga1β1-6Ga1Nacα1-3Ga1β1-4G1c and combinations thereof, 20-95 wt % of at least one neutral oligosaccharide selected from the group consisting of Galβ1-6Gal, Galβ1-6Galβ1-4Glc, Galβ1-6Galβ1-6Glc, Galβ1-3Galβ1-3Glc, Galβ1-3Galβ1-4Glc, Galβ1-6Galβ1-6Galβ1-4Glc, Galβ1-6Galβ1-3Galβ1-4Glc, Galβ1-3Galβ1-6Galβ1-4Glc, Galβ1-3Galβ1-3Galβ1-4Glc and combinations thereof and 2-50 wt % of at least one sialylated oligosaccharide selected from the group consisting of NeuAcα2-3Galβ1-4Glc, NeuAcα2-6Ga1β1-4G1c and combinations thereof. The invention extends to food products comprising said preparation and to the use of the preparation in the prevention and treatment of infections.