Synchronized Pump Flow Balancing for Extracorporeal Blood Processing

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Solution Overview

Problem

Existing extracorporeal blood treatment systems face challenges in achieving precise fluid balance at higher flow rates due to inaccuracies in external pumps and calibration issues, leading to inadequate patient fluid management.

Innovation Solution

Implementing a system with multiple synchronized volumetric or fixed-displacement pumps to control inflows and outflows, using imbalance detection methods such as weight or pressure changes, and pressure sensors to adjust pump rates for accurate fluid balance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If external pumps are used to control fluid flow in extracorporeal blood treatment systems, then the system can achieve fluid balance at lower flow rates, but the calibration inaccuracies and pump errors become significant at higher flow rates leading to inadequate patient fluid management

Engineering Contradiction:
Improvefluid balance accuracyVSAvoidpatient fluid management
Core Design Contradiction:
Measurement precisionVSReliability

Solution Approach 1:

The system employs a feedback mechanism where a flow sensor continuously monitors the actual flow rate and compares it with the target flow rate. The controller adjusts the pump operation in real-time based on this feedback to maintain accurate fluid balance, thereby resolving the contradiction between measurement precision and reliability at higher flow rates.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent replaces reliance on mechanical pump calibration with an electronic control system that uses a flow sensor and controller to actively regulate pump performance. This substitution of mechanical precision with electronic control and sensing eliminates the fundamental limitations of pump calibration inaccuracies.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Adaptability or versatility

If multiple therapy fluid inlet flows are used to achieve overall patient fluid balance, then more comprehensive fluid control is possible, but the complexity of synchronizing multiple pumps increases system complexity

Engineering Contradiction:
Improvefluid balance controlVSAvoidpump synchronization system
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent merges the control of multiple therapy fluid pumps into a single integrated control system. The controller receives feedback from a flow sensor and coordinates all pumps to work together as a unified system, simplifying the synchronization task while maintaining the versatility of multiple fluid streams.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The controller is designed as a universal control unit that can manage multiple different types of pumps and fluid streams. This multi-functional controller handles synchronization, flow regulation, and balance maintenance for all therapy fluid inlet flows, reducing overall system complexity despite the increased adaptability.

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Measurement precision

If balance chambers are used to balance single inlet fluid flow with effluent stream, then volumetric balance can be achieved, but the system is limited to single therapy fluid inlet flow

Engineering Contradiction:
Improvevolumetric balanceVSAvoidtherapy fluid flow support
Core Design Contradiction:
Measurement precisionVSAdaptability or versatility

Solution Approach 1:

The system employs multiple independent pumps, each capable of handling different therapy fluid inlet flows. This multi-functional pump configuration allows the system to support various fluid streams (predilution, post-dilution, citrate infusion, reverse ultrafiltration) while maintaining volumetric balance through centralized control.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The feedback mechanism monitors the combined effect of all therapy fluid flows and effluent streams. The controller adjusts individual pump rates based on this feedback to maintain overall volumetric balance, enabling the system to handle multiple fluid streams while preserving the precision of volume control.

Inventive Principle:
Principle #23Feedback

Data Source

PatentUS20250303037A1Flow Balancing Devices, Methods, and Systems
Publication Date: 2025.10.02 NXSTAGE MEDICAL INC
  • US20250303037A1 patent drawing
  • US20250303037A1 patent drawing
  • US20250303037A1 patent drawing

AI summary

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.