Synergistic Active Substance Combinations for Pest Control

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Solution Overview

Problem

Current insecticidal and acaricidal compounds fail to meet agricultural requirements for effective pest control, particularly at low application rates, and have limitations in controlling resistant pests, plant tolerance, and environmental safety.

Innovation Solution

Combining specific compounds of formula (I) with macrolides, carboxylates, or other active substances to create synergistic active substance combinations that enhance insecticidal and acaricidal activity, reducing dosage rates and expanding pest control spectra while ensuring safety and plant compatibility.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If compounds of formula (I) or macrolides/carboxylates are used individually, then insecticidal activity is achieved, but the activity is insufficient at low application rates and against resistant pests

Engineering Contradiction:

Improveinsecticidal activityVSAvoiddosage rate

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent combines compound (I) with macrolides or carboxylates in specific ratios (1:4 to 4:1) to create synergistic mixtures that achieve superior insecticidal activity at lower application rates compared to individual compounds

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates composite active substance formulations containing compound (I) together with macrolides or carboxylates, where the composite mixture exhibits enhanced efficacy and spectrum of activity beyond what either component achieves alone

Inventive Principle:

Principle #40Composite materials

2Reliability

If higher dosage rates are used to improve pest control efficacy, then insecticidal activity increases, but plant tolerance decreases and phytotoxicity increases

Engineering Contradiction:

Improvepest control efficacyVSAvoidphytotoxicity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent optimizes the concentration parameters of compound (I) (0.01-1000 g/ha) and macrolides/carboxylates (0.01-1000 g/ha) within specific ranges to achieve effective pest control while maintaining plant safety and avoiding phytotoxicity

Inventive Principle:

Principle #35Parameter changes

3Adaptability or versatility

If broader spectrum insecticides are used to control multiple pests including resistant strains, then pest control spectrum widens, but toxicity to non-target organisms increases

Engineering Contradiction:

Improvepest control spectrumVSAvoidtoxicity to non-target organisms

Core Design Contradiction:

Adaptability or versatilityVSObject-generated harmful factors

Solution Approach 1:

The patent segments the pest control approach by combining two different chemical classes (compound I and macrolides/carboxylates) with different mechanisms of action, achieving broad spectrum coverage while maintaining selectivity and reduced non-target toxicity through the specific synergistic combination

Inventive Principle:

Principle #1Segmentation

Data Source

PatentUS9173394B2Active agent combinations having insecticidal and acaricidal properties

Publication Date: 2015.11.03 BAYER CROPSCIENCE AG

AI summary

The present invention relates to novel active substance combinations which contain firstly at least one known compound of the formula (I)in whichR1 and A have the meanings given in the description,and secondly at least one further known active substance from the class of the macrolides, the carboxylates or other classes, and which are highly suitable for controlling animal pests such as insects and undesired acarids.