Synergistic Active Substance Combinations for Pest Control

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Solution Overview

Problem

Current insecticidal compounds fail to meet agricultural requirements, such as reducing dosage rates, controlling resistant pests, and ensuring safety and efficacy on plant propagation materials, while maintaining low toxicity to plants and warm-blooded species.

Innovation Solution

Combining specific compounds of formula (I) with neonicotinoids, like thiacloprid and imidacloprid, to create synergistic active substance combinations that enhance insecticidal and acaricidal activity, widening the pest control spectrum and improving safety and plant tolerance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If compounds of formula (I) or neonicotinoids are used individually, then insecticidal activity is achieved, but dosage rates are too high and spectrum of control is insufficient

Engineering Contradiction:
Improvedosage rateVSAvoidspectrum of pests controlled
Core Design Contradiction:
Quantity of substanceVSAdaptability or versatility

Solution Approach 1:

The patent combines compounds of formula (I) with neonicotinoids in synergistic mixtures, where the combination achieves broader pest spectrum control and allows reduced dosage rates compared to individual compounds. The synergistic interaction between the two compound classes enhances overall efficacy while reducing the quantity of each substance needed.

Inventive Principle:
Principle #5Merging (Combining)

2Reliability

If higher dosage rates are used to control resistant pests, then pest control efficacy is improved, but toxicity to plants and warm-blooded species increases

Engineering Contradiction:
Improvepest control efficacyVSAvoidtoxicity to plants and warm-blooded species
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical composition parameters by combining two different compound classes (formula (I) compounds and neonicotinoids) with different modes of action. This parameter change allows control of resistant pests through synergistic effects while maintaining lower individual dosage rates, thereby reducing toxicity to non-target organisms including plants and warm-blooded species.

Inventive Principle:
Principle #35Parameter changes

3Device complexity

If single active substances are used, then application simplicity is maintained, but additional effects such as fungicidal or nematicidal activity are not achieved

Engineering Contradiction:
Improvecomposition complexityVSAvoidadditional biocidal effects
Core Design Contradiction:
Device complexityVSAdaptability or versatility

Solution Approach 1:

The patent creates a multi-functional active substance combination where the mixture of compounds of formula (I) and neonicotinoids provides not only insecticidal activity but also additional effects such as fungicidal, nematicidal, and acaricidal properties. This universal approach allows a single application to address multiple pest types and additional plant pathogens, enhancing versatility without significantly increasing application complexity.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentUS8455480B2Active agent combinations having insecticidal and acaricidal properties
Publication Date: 2013.06.04 BAYER CROPSCIENCE AG
  • US8455480B2 patent drawing
  • US8455480B2 patent drawing
  • US8455480B2 patent drawing

AI summary

The present invention relates to novel active substance combinations which contain firstly at least one known compound of the formula (I)in whichR1 and A have the meanings given in the description,and secondly at least one further known active substance from the class of the neonicotinoids, and which are highly suitable for controlling animal pests such as insects and undesired acarids.