Synergistic Biocidal Composition for Low-Dose Broad-Spectrum Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current bactericidal, virucidal, and fungicidal agents are environmentally harmful, costly, and can induce resistance, with high minimum inhibitory concentrations necessitating high dosages that increase adverse reactions.
Innovation Solution
A composition comprising 5-isopropyl-2-methylphenol, 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane, 4-methyl-1-(propan-2-yl)cyclohex-3-en-1-ol, and optionally 5-methyl-2-(propan-2-yl) phenol or 5-methyl-2-(propan-2-yl)cyclohexan-1-ol, demonstrating synergistic biocidal activity at low concentrations, effective against a broad spectrum of pathogens including antibiotic-resistant strains and biofilms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional biocidal agents (quaternary ammonium salts, ethanol) are used, then broad-spectrum biocidal activity is achieved, but environmental harm increases and resistance develops
Solution Approach 1:
The invention changes the chemical composition parameters by using specific natural compounds (carvacrol, eucalyptol, terpinen-4-ol in defined ratios) instead of conventional synthetic biocides. This parameter change maintains biocidal effectiveness while eliminating the environmental harm associated with quaternary ammonium salts and ethanol, resolving the contradiction between reliability and environmental safety.
Solution Approach 2:
The invention employs readily available natural compounds from essential oils that can be produced sustainably, replacing expensive and environmentally damaging synthetic alternatives. The use of natural, biodegradable components ensures environmental safety while maintaining biocidal function.
2Object-affected harmful factors
If essential oils are used as biocidal agents, then natural origin and environmental safety are improved, but production cost increases due to high raw material requirements
Solution Approach 1:
The invention merges multiple essential oil components (carvacrol from 0.1-45%, eucalyptol from 0.1-45%, terpinen-4-ol from 0.1-60%) into a synergistic formulation. This combination achieves enhanced biocidal activity at lower total concentrations than individual essential oils, reducing the raw material quantity needed and thereby lowering production costs while maintaining environmental safety.
Solution Approach 2:
The invention creates a composite biocidal formulation combining specific ratios of natural compounds. This composite approach leverages synergistic interactions between components to achieve higher efficacy per unit mass, reducing the overall amount of natural material required and consequently reducing production costs compared to using single essential oils.
3Reliability
If high concentrations of essential oil active ingredients are used, then biocidal effectiveness is improved, but adverse reactions increase and production cost increases
Solution Approach 1:
The invention combines multiple essential oil components in specific proportions (carvacrol 0.1-45%, eucalyptol 0.1-45%, terpinen-4-ol 0.1-60%) to achieve synergistic biocidal activity. This combination allows the use of lower total concentrations while maintaining or enhancing effectiveness, thereby reducing adverse reactions associated with high concentrations of single ingredients.
Solution Approach 2:
The invention optimizes the concentration parameters of individual components within specific ranges, achieving effective biocidal activity at lower overall concentrations. The synergistic interaction between components allows each to work more efficiently, reducing the need for high dosages and consequently minimizing adverse reactions.
4Speed
If conventional biocidal agents are used, then immediate biocidal activity is achieved, but prolonged use generates resistance reducing effectiveness
Solution Approach 1:
The invention uses a composite formulation of multiple natural compounds (carvacrol, eucalyptol, terpinen-4-ol) that work synergistically. This multi-component approach prevents resistance development that occurs with single-agent conventional biocides, as pathogens cannot easily adapt to multiple simultaneous mechanisms of action, thereby maintaining long-term effectiveness while preserving rapid biocidal activity.
Data Source
AI summary
The invention refers to compositions comprising: (a) from 25% to 43% by weight of 5-Isopropil-2-metilfenol (carvacrol); (b) from 20% to 38% by weight of 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane (eucalyptol); and (c) from 21% to 38% by weight of 4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol (terpinen-4-ol) being the sum of ingredients up to 100% by weight. The compositions have a strong biocidal activity. The invention also refers to products comprising the composition and also to the uses thereof.