Synergistic Herbicidal Composition for Resistant Weed Control
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Solution Overview
Problem
Current herbicidal compositions and methods are inadequate for effectively controlling undesirable vegetation in agriculture, as they often lack synergistic effects and are not suitable for all crop types and weed species, particularly those resistant or tolerant to multiple herbicides.
Innovation Solution
A synergistic herbicidal composition comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid or its esters, combined with cellulose biosynthesis inhibitors like indaziflam and isoxaben, which exhibit enhanced herbicidal activity when used together, allowing for effective control of a wide range of weeds including resistant and tolerant biotypes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional herbicides are used alone, then application simplicity is maintained, but weed control efficacy is insufficient particularly against resistant biotypes
Solution Approach 1:
The patent combines compound (I) with cellulose biosynthesis inhibitors (CBIs) in a single herbicidal composition to achieve synergistic weed control. This merging of two different herbicidal mechanisms addresses the insufficient efficacy of single herbicides against resistant biotypes while maintaining practical application simplicity through formulation integration.
Solution Approach 2:
The invention creates a composite herbicidal composition containing compound (I) and CBI at specific ratio ranges (e.g., 1:4 to 4:1 weight ratios). This composite approach leverages the complementary modes of action between the two herbicide types, producing enhanced control efficacy that neither component achieves alone, particularly against herbicide-resistant weeds.
2Adaptability or versatility
If single herbicide modes of action are used, then resistance development is slowed, but control spectrum is limited
Solution Approach 1:
The herbicidal composition serves multiple functions simultaneously: it provides broad-spectrum weed control through compound (I)'s activity while also delivering CBI's specific cellulose synthesis inhibition. This multi-functionality enables the single composition to address diverse weed species and resistance mechanisms, expanding the control spectrum without compromising resistance management.
Solution Approach 2:
The invention changes the herbicidal action parameters by introducing a second mechanism of action (CBI) that operates independently from compound (I). This parameter diversification allows the composition to有效控制 weeds that may be resistant to one mode of action while maintaining resistance management through the dual-mechanism approach.
3Reliability
If higher herbicide doses are applied, then weed control efficacy is improved, but phytotoxicity to crops increases
Solution Approach 1:
The patent converts the potential harm of increased herbicide dosing into a benefit through synergistic interaction. By combining compound (I) with CBI at optimized ratios, the composition achieves enhanced weed control efficacy at lower total doses than would be required for either herbicide alone, thereby reducing crop phytotoxicity while improving effectiveness.
Solution Approach 2:
The invention optimizes the concentration parameters of both herbicides in the composition to achieve synergistic effects at reduced doses. The specific ratio ranges disclosed (e.g., 1:4 to 4:1) represent parameter optimization that maximizes weed control while minimizing phytotoxicity, allowing effective treatment without the need for excessive herbicide application.
Data Source
AI summary
Provided herein are synergistic herbicidal compositions containing (a) a compound of formula (I): 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid or a derivative thereof, or an agriculturally acceptable salt or ester thereof and (b) a cellulose biosynthesis inhibitor, e.g., indaziflam and isoxaben. The methods and compositions described herein provide control of undesirable vegetation, e.g., in direct-seeded, water-seeded and transplanted rice, cereals, wheat, barley, oats, rye, sorghum, corn or maize, sugarcane, sunflower, oilseed rape, canola, sugar beet, soybean, cotton, pineapple, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, aquatics, plantation crops, vegetables, industrial vegetation management (IVM) or rights-of-way (ROW).