Synergistic Microbicidal Composition for Rapid Inactivation

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Solution Overview

Problem

Commercial microbicides often fail to provide effective control of microorganisms, especially resistant strains and in aggressive environmental conditions, leading to inadequate antimicrobial action during short cleaning periods, which can result in inadequate bacterial removal and increased risk of disease transmission.

Innovation Solution

A synergistic microbicidal composition combining specific phenolic compounds and antimicrobial alcohols, such as 2-methyl-5-(prop-1-en-2-yl)cyclohexanol and isopropyl methyl phenols, which exhibit enhanced antimicrobial efficacy at lower concentrations, achieving rapid microbial inactivation within 15 seconds.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If chlorine-based antimicrobial agents such as triclosan are used, then antimicrobial action is provided, but the contact time required is rather long

Engineering Contradiction:
Improveantimicrobial actionVSAvoidcontact time
Core Design Contradiction:
ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent combines multiple microbicides (at least two different microbidal compounds) in a single composition to achieve synergistic effects. This merging of multiple agents allows for faster and more effective antimicrobial action compared to using a single agent, thereby reducing the required contact time while maintaining reliability of antimicrobial action.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention uses composite microbicidal compositions containing multiple microbidal compounds working together. This composite approach enables the composition to achieve effective antimicrobial action more rapidly than individual microbicides, addressing the contradiction between reliability and contact time requirement.

Inventive Principle:
Principle #40Composite materials

2Reliability

If known antimicrobials are used in hard surface cleaning, then microbial control is provided, but the cleaning action is ineffective due to long contact times required

Engineering Contradiction:
Improvemicrobial controlVSAvoidcleaning efficiency
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The patent employs combinations of multiple microbicides to achieve rapid microbial inactivation during short cleaning periods. This synergistic combination enables effective microbial control without requiring prolonged contact times, thereby improving cleaning efficiency and productivity in hard surface cleaning applications.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention changes the temporal parameter of microbial inactivation by using synergistic microbicide combinations that act rapidly. This parameter change allows the composition to achieve effective microbial control within short contact times (seconds to minutes), thereby improving cleaning efficiency and making it suitable for high-speed cleaning operations.

Inventive Principle:
Principle #35Parameter changes

3Reliability

If high concentrations of individual microbicides are used, then effective control is achieved, but safety and environmental concerns increase

Engineering Contradiction:
Improvemicrobial controlVSAvoidsafety and environmental impact
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines multiple microbicides in synergistic proportions, allowing for effective microbial control at lower concentrations of individual agents. This merging approach reduces the harmful effects and safety concerns associated with high concentrations of single microbicides, while maintaining reliable microbial control through the combined action of multiple agents.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention changes the concentration parameter by using synergistic combinations that achieve effective microbial control at lower individual microbicide concentrations. This parameter change reduces the harmful factors and safety issues associated with high concentrations, while maintaining effective microbial control through enhanced synergistic action.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The synergistic composition provides fast and effective antimicrobial action, ensuring complete microbial inactivation in short contact times, reducing the risk of disease transmission and improving hygiene in personal and industrial cleaning applications.

Implementation Method 1

a synergistic combination of selected microbicides having greater activity than would be observed for the individual microbicides

Methodology Applied
Scientific EffectSynergistic combination effect:

Implementation Method 2

comprising: (a) at least one microbicide selected from the group consisting of 2-methyl-5-(prop-1-en-2-yl)cyclohex-2-enol, 2-methyl-5-(prop-1-en-2-yl)cyclohexanol and 5-methyl-2-(prop-1-en-2-yl)cyclohexanol

Methodology Applied
Scientific EffectChemical antimicrobial action:

Data Source

PatentEP2787827B2Microbicidal composition
Publication Date: 2021.11.10 UNILEVER NV
  • EP2787827B2 patent drawing
  • EP2787827B2 patent drawing
  • EP2787827B2 patent drawing

AI summary

A synergistic microbicidal composition comprising: (a) at least one microbicide selected from the group consisting of a monosubstituted phenol and an isopropyl methyl phenol;and (b)at least one microbicide selected from the group consisting of substituted cyclohexyl propyl-1,3-diols, propen-2yl-methyl cyclohexanols and menthadiene alcohols.