Synthetic Microbial Bioensembles for Early-Stage Equine Colic
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Solution Overview
Problem
Existing treatments for equine colic, often induced by microbial stress or poor diet, are inadequate in addressing early-stage microbial-based forms and preventing progression to symptomatic colic.
Innovation Solution
A microbial composition comprising specific bacteria strains with 16S nucleic acid sequences similar to SEQ ID NOs: 1-574, formulated with carriers for equine administration, is used to treat and prevent colic by reducing symptoms and frequency of episodes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used for equine colic, then symptomatic relief may be achieved, but early-stage microbial-based forms of colic are not effectively addressed and progression to severe colic is not prevented
Solution Approach 1:
The patent applies preliminary action by administering specific probiotic bacteria strains (such as Clostridium butyricum, Bifidobacterium animalis, and Lactobacillus acidophilus) before colic symptoms fully develop. These microorganisms colonize the equine gut in advance, establishing a beneficial microbial population that prevents early-stage microbial imbalances from progressing to symptomatic colic, thereby addressing the problem before it manifests severely.
Solution Approach 2:
The patent converts the harmful effect of microbial stress into a beneficial outcome by using specific probiotic strains that outcompete pathogenic microbes. The administered bacteria produce beneficial metabolites (such as short-chain fatty acids) that create an environment hostile to harmful microbes while supporting gut health, thus transforming the microbial challenge into a therapeutic opportunity.
2Adaptability or versatility
If a broad-spectrum approach to colic treatment is used, then various forms of colic may be addressed, but targeted treatment of microbial-based causes is insufficient
Solution Approach 1:
The patent applies local quality by selecting specific probiotic bacterial strains with known beneficial properties for equine gut health. Rather than using a generic mixture, the invention specifies particular species (Clostridium butyricum, Bifidobacterium animalis, Lactobacillus acidophilus) that have demonstrated ability to address microbial imbalances in the equine gastrointestinal tract, providing targeted intervention for microbial-based colic causes.
Solution Approach 2:
The patent applies parameter changes by carefully controlling the composition, concentration, and ratio of different probiotic strains in the formulation. The specific parameters include the types of bacteria present, their relative abundances, and the delivery vehicle characteristics, all optimized to maximize therapeutic effect on microbial-based colic while maintaining safety and efficacy.
3Reliability
If preventive treatment is administered to all equines, then progression to symptomatic colic may be prevented, but treatment of equines without microbial-based colic risk is unnecessary
Solution Approach 1:
The patent enables preventive treatment by administering probiotic bacteria before colic develops or in early-stage cases. The beneficial microbes establish colonization in advance, creating a protective effect that prevents progression to symptomatic colic. This preliminary intervention can be applied selectively based on risk assessment, allowing prevention in susceptible equines without unnecessary treatment of all animals.
Data Source
AI summary
The disclosure relates to isolated microorganisms, including novel strains of the microorganisms, synthetic bioensembles, and compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, synthetic bioensembles, and compositions comprising the same, in methods for modulating the health of equine animals. In particular aspects, the disclosure provides methods of treating and/or preventing colic and shifting the gut microbiome.