Prefillable Syringe Bypass Channel Isolation
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Solution Overview
Problem
Prefilled syringes face issues with prolonged contact of medicinal products with impurities during storage, leading to undesirable reactions due to contact with tungsten residues, metal needles, and adhesives, which can affect the effectiveness and safety of biotechnological active ingredients.
Innovation Solution
A prefillable syringe design with a hollow-cylindrical syringe body and a hollow-cylindrical end piece featuring a bypass channel that separates the storage area from the end piece, allowing a fluidic connection only during dispensing, minimizing contact with potentially risky materials during storage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If the reservoir is positioned close to the passage channel for compact design, then device complexity is reduced, but the medium comes into prolonged contact with tungsten residues, metal needles, and adhesives during storage, compromising medication integrity
Solution Approach 1:
The syringe is segmented into distinct functional zones: a reservoir area for medication storage, a distal spacer area free from contaminants, and an end piece with the passage channel. This spatial segmentation allows the medication to be isolated from harmful materials during storage while maintaining a compact overall structure.
Solution Approach 2:
The distal spacer area acts as an intermediary zone between the reservoir and the passage channel. It provides a buffer space that prevents direct contact between the medium and potential contaminants (tungsten residues, metal needles, adhesives) while still allowing the bypass channel to connect the reservoir to the passage channel when needed.
2Object-affected harmful factors
If a bypass channel is introduced to separate the reservoir from the passage channel, then contact with impurities is minimized, but device complexity and structural requirements increase
Solution Approach 1:
The bypass channel is integrated directly into the syringe body wall, merging the separation function with the existing structural components. This eliminates the need for separate external mechanisms and keeps the overall device complexity manageable while achieving the goal of minimizing contact with impurities.
3Manufacturing precision
If the forming pin is made of tungsten for high-temperature processing, then manufacturing precision is maintained, but abrasion occurs during use, contaminating the channel with tungsten residues
Solution Approach 1:
The harmful tungsten residues generated during forming are effectively removed from the medication pathway by the distal spacer area and bypass channel design. The spacer creates a zone where any potential contamination is excluded from direct contact with the medium, and the bypass channel provides an alternative route that avoids contaminated areas.
Data Source
Figure 1~3
Figure 4~7
Figure 8a~8d
AI summary
The invention relates to a prefillable syringe for medical applications with a hollow cylindrical syringe body extending along an axial axis (X), at the distal end of which a hollow cylindrical end piece is formed which has a passage channel, wherein the syringe body comprises a reservoir for a medium intended for administration, wherein in a rest state the reservoir is spaced apart from the passage channel of the hollow cylindrical end piece along the axial axis (X) by a distal spacer area and a first stopper separates the reservoir from the distal spacer area, wherein in a dispensing state a fluidic connection for the medium between the reservoir and the passage channel can be opened via a bypass channel by displacing the first stopper into the distal spacer area.wherein an axial length of the bypass channel extends at least over an axial length of the distal spacing area (8).