Syringe Assembly with Flow Control Member for Drug Vial Adapter
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Solution Overview
Problem
Pre-filled syringes with integral needles or widened tips face challenges in efficient filling with liquid drug contents, as manual filling is time-consuming and prone to errors, leading to potential vaccine wastage due to larger dead volumes compared to standard Luer connectors.
Innovation Solution
A syringe assembly with an integral liquid drug administration device and a drug vial adapter that allows for manual filling and administration, featuring a flow control member that changes positions from initial to final flow path upon detachment of the adapter, enabling efficient aspiration and administration of liquid drug contents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If pre-filled syringes are filled manually with liquid drug dosage, then the syringe can be filled with liquid drug contents, but the filling process is time-consuming and problematic
Solution Approach 1:
The system is divided into distinct components: a syringe assembly with flow control member and a separate drug vial adapter. This segmentation allows the adapter to be detached after filling, exposing the integral needle for administration while eliminating the need for manual filling operations during clinical use.
Solution Approach 2:
The flow control member is pre-configured in an initial position that enables filling flow path establishment when the adapter is attached. The adapter itself is pre-equipped with features (such as the flow control member engagement structures) that facilitate automatic flow path switching upon attachment and detachment, eliminating manual filling time.
2Adaptability or versatility
If standard Luer connector needle hub is used, then the syringe can be equipped with needle, but the dead volume is considerable (0.03 ml to 0.05 ml) which can lead to vaccine wastage
Solution Approach 1:
The traditional Luer connector needle hub is replaced by an integral needle design where the needle is directly attached to the syringe tip. The flow control member and adapter system extract the unnecessary dead volume associated with standard Luer connectors, reducing vaccine waste to minimal levels while maintaining adaptability through the adapter interface.
3Ease of operation
If the integral liquid drug administration device is exposed immediately, then administration can be performed, but the filling process cannot be performed efficiently
Solution Approach 1:
The flow control member is designed to be dynamic, automatically switching between initial and final positions based on the attachment state of the drug vial adapter. When the adapter is attached, the flow control member enables filling flow path; when detached, it switches to enable administration flow path, providing operational readiness without compromising filling efficiency.
Solution Approach 2:
The drug vial adapter acts as an intermediary component that mediates between the filling operation and the administration operation. Its attachment enables efficient filling through the flow control member, and its detachment automatically exposes the integral needle for administration, resolving the contradiction between filling efficiency and administration readiness.
Data Source
AI summary
Syringe assemblies including a syringe pre-equipped with an integral liquid drug administration device for enabling administration of liquid drug contents and a drug vial adapter for telescopic mounting on a drug vial containing liquid drug contents. The drug vial adapter is initially mounted on the syringe and is intended to be manually detached therefrom to expose the integral liquid drug administration device. The syringe includes a flow control member having an initial flow path position for enabling filling the syringe with liquid drug contents from the drug vial and a final flow path position for enabling administration of liquid drug contents. Detachment of the drug vial adapter from the syringe urges the flow control member from its initial flow path position to its final flow path position.