Syringe Plunger Stabilization for Small Volume Dose Accuracy

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Solution Overview

Problem

Existing syringes face challenges in accurately loading and delivering small volume doses of medication due to deformable plungers, leading to inconsistent delivery, especially for medications requiring precise dosages.

Innovation Solution

A syringe loading and delivery system comprising a syringe delivery ring and a syringe loading guide, which stabilize the plunger to ensure accurate delivery of small volumes by preventing the plunger seal from deforming during use.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If a deformable plunger seal is used in the syringe, then the plunger can be compressed to deliver medication, but the plunger seal deforms when contacting the distal end of the syringe barrel, leading to larger than intended volume delivery

Engineering Contradiction:
Improveplunger compressionVSAvoiddose volume accuracy
Core Design Contradiction:
Ease of operationVSManufacturing precision

Solution Approach 1:

A stopper is introduced as an intermediary component between the plunger seal and the distal end of the syringe barrel. The stopper has a flat end surface that contacts the plunger seal, preventing direct contact between the deformable plunger seal and the barrel end. This intermediary structure maintains the compressibility function while eliminating the deformation problem that causes dose inaccuracy.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Ease of manufacture

If existing loading systems are used, then the syringe can be loaded with medication, but the systems provide insufficient stability to accurately load small volume doses

Engineering Contradiction:
Improveloading processVSAvoidsmall volume dose accuracy
Core Design Contradiction:
Ease of manufactureVSMeasurement precision

Solution Approach 1:

The stopper is pre-positioned in the syringe barrel at a specific location before the loading process. This preliminary positioning establishes a fixed reference point that ensures the plunger seal will contact the stopper at the correct position, enabling accurate loading of small volume doses. The stopper's position is predetermined to achieve the desired dose volume, eliminating the need for complex loading systems.

Inventive Principle:
Principle #10Preliminary action

3Device complexity

If the plunger seal is allowed to contact the distal end of the syringe barrel, then the syringe structure remains simple, but the plunger seal deformation leads to inconsistent medication delivery

Engineering Contradiction:
Improvesyringe structureVSAvoidmedication delivery consistency
Core Design Contradiction:
Device complexityVSReliability

Solution Approach 1:

The stopper serves as a simple intermediary component that contacts the plunger seal before it can reach the distal end of the barrel. This adds minimal structural complexity while dramatically improving delivery consistency. The stopper's flat end surface provides a reliable stopping point that ensures the plunger seal maintains its shape and sealing function throughout the delivery process.

Inventive Principle:
Principle #24Intermediary (Mediator)

Data Source

PatentEP3749386B1Systems, kits and methods for loading and delivering a small volume dose from a syringe
Publication Date: 2026.04.15 ICON BIOSCIENCE INC
  • EP3749386B1 patent drawingFigure 1
  • EP3749386B1 patent drawingFigure 1A
  • EP3749386B1 patent drawingFigure 1B

AI summary

A kit is disclosed for accurately loading a small volume dose of a medication within a syringe and for delivering the small volume dose of the medication at a treatment site. The kit generally includes a loading and delivery system in accordance herewith, a syringe, and a medication. The loading and delivery system includes a syringe delivery ring and a syringe loading guide, which may be used for example, to administer a small volume dose of a medication at the end of an ocular surgery.