System and methods for treatment of wounds with negative pressure and peroxy pyruvic acid
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current wound treatment methods using negative-pressure therapy and instillation lack effectiveness in addressing the growing threat of healthcare-associated infections and biofilms, particularly with resistant pathogens like MRSA and C. difficile spores, and require frequent intervention for wound assessment and treatment.
Innovation Solution
The integration of antimicrobial solutions containing peroxy α-keto carboxylic acids, such as peroxy pyruvic acid, with negative-pressure and instillation therapy systems, which deliver these solutions to the wound site using a dressing and control pressure modes to enhance tissue granulation and infection control.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional negative-pressure therapy and instillation are used, then wound cleansing and tissue growth promotion are achieved, but effectiveness against resistant pathogens like MRSA and C. difficile spores is insufficient
Solution Approach 1:
The patent changes the chemical parameter of the instillation solution by using peroxy pyruvic acid instead of conventional saline or antimicrobial solutions. This chemical substitution provides enhanced broad-spectrum antimicrobial activity against resistant pathogens including MRSA and C. difficile spores, while maintaining tissue compatibility and promoting wound healing through controlled decomposition into beneficial byproducts.
Solution Approach 2:
The patent creates a composite therapeutic approach by combining negative-pressure mechanical therapy with chemically active peroxy pyruvic acid instillation. This composite system integrates physical debridement and drainage effects with chemical antimicrobial action and tissue stimulation, achieving synergistic effects that overcome limitations of either modality alone against resistant infections.
2Reliability
If frequent wound assessment and intervention are performed, then infection control is improved, but treatment complexity and resource requirements increase
Solution Approach 1:
The patent implements continuous antimicrobial action through sustained negative-pressure therapy combined with ongoing peroxy pyruvic acid instillation. This continuous therapeutic presence maintains effective antimicrobial concentrations and mechanical forces throughout the treatment period, providing constant protection against infection without requiring repeated discrete interventions or assessments.
Solution Approach 2:
The peroxy pyruvic acid solution provides self-sustaining therapeutic action by decomposing into beneficial compounds (pyruvic acid, hydrogen peroxide, oxygen) that continue to exert antimicrobial and tissue-stimulating effects. This self-activating chemical system reduces the need for frequent manual reassessment and intervention, as the therapy maintains itself through the controlled decomposition process.
3Object-affected harmful factors
If strong antimicrobial agents are used to combat resistant pathogens, then infection control improves, but damage to healthy tissue may occur
Solution Approach 1:
The patent applies antimicrobial action locally and selectively at the wound site through controlled instillation of peroxy pyruvic acid. The solution concentrates antimicrobial activity precisely where needed in the wound bed and biofilm environments, while the negative-pressure system ensures the agent remains localized to the treatment area. This localized application achieves potent pathogen elimination without exposing surrounding healthy tissue to damaging concentrations.
Solution Approach 2:
The patent transforms the chemical parameters of the antimicrobial agent over time through controlled decomposition. Peroxy pyruvic acid initially provides strong oxidizing antimicrobial action against resistant pathogens, then gradually decomposes into pyruvic acid and hydrogen peroxide at lower concentrations that continue to provide gentler antimicrobial and tissue-stimulating effects. This temporal parameter change allows aggressive initial pathogen elimination followed by milder tissue-healing phases, avoiding sustained tissue damage.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly increases granulation tissue thickness, effectively mitigates healthcare-associated infections, and reduces the need for frequent wound assessments by promoting wound healing and biofilm breakdown while maintaining safety for healthy tissue.
Implementation Method 1
The antimicrobial solution decomposes into byproducts, such as pyruvic acid and hydrogen peroxide
Implementation Method 2
a negative-pressure source fluidly coupled to the dressing and adapted to provide negative pressure to the therapeutic environment
Implementation Method 3
a positive-pressure source fluidly coupled to the solution source and adapted to actuate the solution source for delivering the antimicrobial solution
Implementation Method 4
a dressing adapted to contact the tissue site and provide a fluid seal between a therapeutic environment and a local external environment
Data Source
AI summary
In one example embodiment, a system for treating a tissue site is disclosed comprising a dressing adapted to contact the tissue site and provide a fluid seal between a therapeutic environment and a local external environment, and a solution source fluidly coupled to the dressing and adapted to deliver an antimicrobial solution comprising a peroxy α-keto carboxylic acid, such as peroxy pyruvic acid, to the tissue interface. The system may further comprise a negative-pressure source fluidly coupled to the dressing and adapted to provide negative pressure to the therapeutic environment after delivery of the antimicrobial fluid to the therapeutic environment. In another example embodiment, a method for treating a tissue site is disclosed comprising positioning a tissue interface to contact the tissue site, covering the tissue interface and the tissue site with a drape to provide a fluid seal between the therapeutic environment and the local external environment, and delivering an antimicrobial solution comprising peroxy α-keto carboxylic acid to the therapeutic environment before providing negative pressure to the therapeutic environment.