Aqueous Syzygium Aromaticum Solution for Mucocutaneous Disinfection

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Solution Overview

Problem

Existing mucocutaneous solutions for preventing or treating infectious diseases often cause discomfort, are habit-forming, or have undesirable effects due to their pH levels and use of alcohol in extraction processes, limiting their effectiveness and safety for long-term use.

Innovation Solution

A mucocutaneously administered aqueous solution with a pH of 7.5 or greater, using a plant matrix from the Myrtaceae family, such as Syzygium aromaticum, in an alcohol-free solvent like seawater, which is extracted through methods like infusion or maceration to achieve analgesic, anti-inflammatory, anti-parasitic, anti-fungal, and antibacterial properties.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional nasal washing products with basic pH are used, then disinfection effect is improved, but user comfort deteriorates due to tingling or burning sensations

Engineering Contradiction:
Improvedisinfection effectVSAvoidtingling or burning sensations
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the pH parameter from basic (traditional) to acidic (pH 3-6), which simultaneously provides effective disinfection while avoiding the tingling or burning sensations caused by basic pH solutions. This parameter change resolves the contradiction between disinfection effectiveness and user comfort.

Inventive Principle:
Principle #35Parameter changes

2Reliability

If medicinal substances such as cortisone are added to nasal washing products, then treatment effectiveness is improved, but safety deteriorates due to habit-forming effects and dangers of long-term use

Engineering Contradiction:
Improvetreatment effectivenessVSAvoidhabit-forming effects and safety risks
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent extracts and removes harmful medicinal substances like cortisone from the nasal washing composition, relying instead on the inherent antimicrobial properties of acidic pH and plant extracts. This eliminates the habit-forming effects and safety risks associated with long-term cortisone use while maintaining treatment effectiveness.

Inventive Principle:
Principle #2Taking out (Extraction)

3Productivity

If alcohol is used as solvent for plant extract preparation, then extraction efficiency is improved, but safety deteriorates due to irritation of skin and mucous membranes

Engineering Contradiction:
Improveextraction efficiencyVSAvoidirritation of skin and mucous membranes
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the solvent parameter from alcohol to water or aqueous solutions, which eliminates the irritation of skin and mucous membranes while maintaining effective extraction of plant active ingredients through optimized maceration or infusion processes.

Inventive Principle:
Principle #35Parameter changes

4Reliability

If daily use of nasal washing products is required to achieve satisfactory results, then treatment effectiveness is improved, but ease of operation deteriorates due to increased frequency requirements

Engineering Contradiction:
Improvetreatment effectivenessVSAvoidfrequency of application
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The patent formulates the composition with sustained-release properties and optimized stability, allowing the active ingredients to maintain their effectiveness over extended periods. This reduces the frequency of application from daily to less frequent use while maintaining treatment effectiveness, thereby improving ease of operation.

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution provides effective prevention and treatment of infectious diseases with reduced discomfort, stability, and tolerance, allowing for longer intervals between applications without habit-forming issues, while maintaining a neutral pH suitable for mucocutaneous use.

Implementation Method 1

a first step of bringing a plant matrix into contact with a basic aqueous solvent, thereby neutralizing the pH of said plant matrix

Methodology Applied
Scientific EffectpH neutralization:

Data Source

PatentUS20240382550A1Aqueous solution based on syzygium aromaticum, and associated preparation method and uses
Publication Date: 2024.11.21 DEBOUK CHARLES

AI summary

The subject matter of the invention is an aqueous solution for mucocutaneous administration, containing a plant matrix selected from plants or parts of plants of the Myrtaceae family in a solvent that is an aqueous solution with a pH of 7.5 or greater. The invention also covers a process for preparing such a solution. The solution according to the invention is used specifically in the prevention or treatment of infectious diseases.