Targeted Fluid Ejection Profiles for Nasal Sub-Regions

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Solution Overview

Problem

Current intranasal drug delivery methods fail to provide on-target delivery to specific sub-regions of the nasal cavity, leading to high off-target delivery and potential damage to delicate therapeutic molecules, especially for large molecule drugs.

Innovation Solution

A method involving the ejection of a low viscosity fluid as a continuous stream from a dispensing element, navigating through the nasal cavity to contact and move around anatomical features, targeting specific sub-regions like the olfactory cleft or middle turbinate without substantial off-target deposition.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If traditional intranasal spray methods are used to maximize coating of the mucosal surface, then mass transfer across the mucosa is maximized, but on-target delivery to specific sub-regions is poor and off-target delivery is high

Engineering Contradiction:

Improvemass transferVSAvoidon-target delivery precision

Core Design Contradiction:

Quantity of substanceVSManufacturing precision

Solution Approach 1:

The invention segments the nasal cavity into specific sub-regions (olfactory cleft, middle turbinate, superior turbinate) and targets each region independently using directed fluid ejection, rather than applying a uniform spray across the entire nasal cavity. This allows precise delivery to selected sub-regions while minimizing off-target deposition.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention applies local quality by delivering fluid with specific properties (viscosity range, ejection velocity, stream configuration) tailored to reach specific sub-regions. The fluid is ejected as a continuous stream or series of discrete volumes that maintain coherence until contact with the target sub-region, ensuring localized delivery rather than diffuse coating.

Inventive Principle:

Principle #3Local quality

2Quantity of substance

If traditional spray methods are used to deliver large molecule drugs, then delivery to the nasal cavity is achieved, but shear stress damages the delicate therapeutic molecules

Engineering Contradiction:

Improvedrug deliveryVSAvoidshear stress damage

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The invention replaces the high-shear mechanical action of traditional spray atomization with a gentler continuous stream ejection mechanism. The fluid is delivered as a coherent stream or series of discrete volumes that maintain lower velocity gradients, reducing shear stress exposure for large molecule drugs while still achieving effective delivery to the target sub-region.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Ease of operation

If low viscosity fluid is used for intranasal delivery, then fluid ejection is easier, but the fluid is difficult to direct to targeted sub-regions without off-target delivery

Engineering Contradiction:

Improvefluid ejectionVSAvoidtargeted sub-region delivery

Core Design Contradiction:

Ease of operationVSManufacturing precision

Solution Approach 1:

The invention changes the ejection parameters (velocity, stream diameter, ejection angle) to match the fluid's low viscosity characteristics. By optimizing these parameters, the system maintains stream coherence and directional control for low viscosity fluids, enabling targeted delivery to specific sub-regions despite the fluid's natural tendency to disperse.

Inventive Principle:

Principle #35Parameter changes

4Speed

If high ejection velocity is used to reach targeted sub-regions, then delivery distance is increased, but off-target deposition increases and therapeutic molecules may be damaged

Engineering Contradiction:

Improveejection velocityVSAvoiddeposition accuracy

Core Design Contradiction:

SpeedVSManufacturing precision

Solution Approach 1:

The invention employs dynamic control of ejection parameters, adjusting velocity, stream configuration, and ejection timing based on the specific target sub-region and fluid properties. This dynamic optimization allows the system to achieve adequate delivery distance while maintaining stream coherence and minimizing off-target deposition through real-time parameter adjustment.

Inventive Principle:

Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enhances on-target delivery to nasal cavity sub-regions, minimizing off-target deposition and reducing the risk of therapeutic molecule damage, enabling precise administration of drugs to areas such as the olfactory cleft and middle turbinate.

Implementation Method 1

moving the continuous stream through an airspace in the nasal cavity towards the targeted sub-region

Methodology Applied

Scientific EffectAerodynamic forces:

Implementation Method 2

contacting an anatomical feature of the subject's nasal cavity with the continuous stream and forcing the fluid to move around the anatomical feature and towards the targeted sub-region

Methodology Applied

Scientific EffectFluid flow around obstacles: Flow Separation

Data Source

PatentUS12403275B2Targeted fluid ejection profiles

Publication Date: 2025.09.02 ROCKET SCI HEALTH CORP

AI summary

Provided herein are methods of delivering a low viscosity fluid to a targeted sub-region of a subject's nasal cavity via delivery as a continuous liquid stream.