Tau-fluvalinate Cyclodextrin Inclusion Complex

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Solution Overview

Problem

Tau-fluvalinate's biological activity is limited by its inability to penetrate insect or plant cuticles effectively due to its physical properties, and existing formulations without cyclodextrin have low efficacy against chewing pests.

Innovation Solution

A solid composition comprising a guest/host molecular structure of tau-fluvalinate and cyclodextrin, combined with agriculturally acceptable fillers, which forms an oil-in-water emulsion upon contact with water, enhancing penetration and efficacy against a broader spectrum of pests.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If tau-fluvalinate is used in conventional formulations without cyclodextrin, then the formulation is simpler to manufacture, but the biological activity against chewing pests is low due to poor penetration of insect cuticle

Engineering Contradiction:

Improvebiological activityVSAvoidformulation complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

Cyclodextrin acts as an intermediary substance that forms an inclusion complex with tau-fluvalinate. The cyclodextrin host molecule encapsulates the tau-fluvalinate guest molecule, creating a composite formulation that enhances penetration through insect cuticle while maintaining manageable formulation complexity. This mediator approach resolves the contradiction by introducing a third component that facilitates the desired biological activity.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent creates a composite formulation consisting of tau-fluvalinate combined with cyclodextrin in specific ratios (1:1 to 1:10 weight ratios). This composite material leverages the properties of both components: tau-fluvalinate provides the insecticidal activity while cyclodextrin enhances penetration and stability. The composite structure resolves the technical contradiction by combining multiple materials to achieve superior biological activity compared to pure tau-fluvalinate formulations.

Inventive Principle:

Principle #40Composite materials

2Reliability

If tau-fluvalinate is formulated to improve penetration of cuticle, then biological activity increases, but physical stability and dispersion properties deteriorate

Engineering Contradiction:

Improvebiological activityVSAvoidphysical stability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

Cyclodextrin serves as a mediator that simultaneously improves penetration and enhances physical stability. The inclusion complex structure protects tau-fluvalinate from degradation while maintaining its ability to penetrate cuticle. This resolves the contradiction by having the intermediary substance perform dual functions: enhancing biological activity through improved penetration and improving physical stability through encapsulation.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent optimizes the weight ratio of tau-fluvalinate to cyclodextrin (specifically 1:1 to 1:10 ranges) to achieve the right balance between penetration capability and physical stability. By adjusting these compositional parameters, the formulation achieves both improved biological activity and enhanced physical stability, resolving the technical contradiction through parameter optimization.

Inventive Principle:

Principle #35Parameter changes

3Ease of manufacture

If tau-fluvalinate is used alone, then the formulation has fewer components, but dispersion over leaves and contact coverage are insufficient

Engineering Contradiction:

Improveformulation simplicityVSAvoiddispersion and contact

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

The composite of tau-fluvalinate and cyclodextrin improves dispersion and contact properties while adding only one additional component. The cyclodextrin component enhances wettability and adhesion to leaf surfaces, improving coverage without requiring multiple separate additives. This resolves the contradiction by achieving improved dispersion and contact through a single composite material rather than multiple separate formulation components.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The tau-fluvalinate-cyclodextrin composition demonstrates increased biological efficacy against chewing pests and improved physical stability, allowing for effective control of plant diseases caused by insects, with enhanced dispersion and reduced sedimentation.

Implementation Method 1

Interacting tau-fluvalinate with cyclodextrin increases its biological activity spectrum and intensity

Methodology Applied

Scientific EffectGuest/host molecular structure formation: Absorption (physical)

Implementation Method 2

which forms an oil-in-water emulsion upon contact with water, enhancing penetration and efficacy

Methodology Applied

Scientific EffectEmulsion formation: Emulsion

Data Source

PatentUS20240023548A1Tau-fluvalinate compositions

Publication Date: 2024.01.25 ADAMA MAKHTESHIM LTD

AI summary

The present invention relates to a solid composition comprising (1) a guest/host molecular structure comprising tau-fluvalinate and cyclodextrin, and (2) at least one agriculturally acceptable filler. The present invention also relates to an oil-in-water emulsion comprising (1) a guest/host molecular structure comprising tau-fluvalinate and cyclodextrin, and (2) at least one agricultural dispersing agent. The present invention further relates to method of use and processes of preparation of the solid compositions and oil-in-water emulsions.