TCM Composition for Cardiovascular Disease via Segmented Extraction
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Solution Overview
Problem
Current treatments for cardiovascular and cerebrovascular diseases, particularly those caused by myocardial diastolic dysfunction, are inadequate, with existing pharmaceuticals showing limited efficacy and safety concerns, and traditional Chinese medicine compositions are complex and difficult to standardize for industrial production.
Innovation Solution
A novel traditional Chinese medicine composition comprising ethanol and aqueous extracts of Rhizoma Chuanxiong, Radix Curcumae, and Radix Cyathulae, potentially combined with Bulbus Allii Macrostemonis and Cortex Eucommiae, formulated into standardized oral dosage forms to treat cardiovascular and cerebrovascular diseases, including those caused by myocardial diastolic dysfunction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional Chinese medicine compositions are used to treat cardiovascular diseases, then therapeutic effects are achieved, but the compositions are complex and difficult to standardize for industrial production
Solution Approach 1:
The patent divides the complex traditional Chinese medicine composition into three distinct parts: a water-soluble extract containing active ingredients, a water-insoluble extract containing active ingredients, and a residue containing active ingredients. This segmentation allows each part to be processed and standardized separately, making industrial production feasible while maintaining the comprehensive therapeutic effects of the original complex composition.
Solution Approach 2:
The patent employs different extraction parameters (water solubility, extraction methods, concentration levels) to separate and isolate active ingredients from the complex mixture. By changing these parameters systematically, the patent achieves standardization of the extraction process while preserving the full spectrum of active components necessary for therapeutic efficacy.
2Reliability
If existing pharmaceuticals are used to treat cardiovascular diseases, then treatment is provided, but efficacy is limited and safety concerns arise
Solution Approach 1:
The patent creates a composite medicinal composition that integrates multiple active ingredients from different sources (water-soluble extracts, water-insoluble extracts, and residues) into a unified formulation. This composite approach combines the benefits of various traditional Chinese medicines to achieve superior efficacy and safety profiles, particularly for treating myocardial diastolic dysfunction, while maintaining adaptability to different patient needs.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition demonstrates significant therapeutic effects on myocardial systolic and diastolic dysfunction, platelet aggregation, thrombosis, myocardial ischemia, hypoxia, and fatigue, with improved safety and stability, comparable to or exceeding the efficacy of modern drugs, and is suitable for industrial production with defined active ingredients.
Implementation Method 1
TCM is based on many chemical components in an herbal preparation that interact and act simultaneously through multiple molecular targets and cellular mechanisms. These multiple components serve various functions; some may be responsible for efficacy while others may decrease toxicity or increase bioavailability.
Implementation Method 2
TCM is based on many chemical components in an herbal preparation that interact and act simultaneously through multiple molecular targets and cellular mechanisms.
Data Source
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AI summary
A traditional Chinese medicine composition for treating cardiovascular and cerebrovascular disease, the active ingredients thereof being composed of: 1) an ethanol extract of 6-12 parts of Ligusticum wallichii and 5-10 parts of Curcumae Radix, and 2) an aqueous extract of extract residue of the described Ligusticum wallichii and Curcumae Radix and 5-10 parts of Achyranthes bidentata; the traditional Chinese medicine composition may further comprise an aqueous extract of 5-10 parts of Allium macrostemon and 6-12 parts of Eucommia ulmoides. The traditional Chinese medicine composition relates to medicine made from plant compounds, and has significant medicinal effects on myocardial contraction disorder and myocardial dilation disorder, platelet aggregation thrombosis and myocardial ischemia, myocardial hypoxia, myocardial fatigue, and so on, being particularly suitable for treating coronary heart disease and chronic or acute heart failure.