TCM Composition for Atherosclerosis Plaque Regression
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Solution Overview
Problem
Current treatments for hyperlipidemia and atherosclerosis, including both chemical lipid-lowering agents and traditional Chinese medicines, face challenges such as high recurrence rates, adverse effects, and inability to fundamentally prevent or control vascular plaques, necessitating a more effective and safer therapeutic option.
Innovation Solution
A traditional Chinese medicine composition comprising thorowax root, immature orange fruit, raw rhubarb, baical skullcap root, white peony root, dried ginger, leech, liquorice root, tangshen, largehead atractylodes rhizome, pinellia tuber, oyster shell, and red yeast rice, which addresses phlegm-fluid retention in the blood to reduce blood lipids, triglycerides, and slow down atherosclerotic plaque formation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If chemical lipid-lowering agents are used long-term, then blood lipid levels are controlled, but adverse effects and toxicities increase
Solution Approach 1:
The patent changes the chemical composition parameters by using natural traditional Chinese medicine ingredients instead of synthetic chemical compounds. The formulation includes multiple herbal extracts with different chemical properties that work synergistically to lower blood lipids through natural metabolic pathways, avoiding the toxic effects of synthetic statins and fibrates.
Solution Approach 2:
The patent employs a composite formulation combining multiple traditional Chinese medicine ingredients (red yeast rice, tangshen, pinellia, etc.) that work together through different mechanisms. This composite approach addresses blood lipid control through multiple pathways simultaneously, reducing reliance on high doses of single agents and thereby minimizing adverse effects.
2Reliability
If synthetic chemical lipid-lowering agents are used, then blood lipid levels are reduced, but recurrence rate increases after treatment discontinuation
Solution Approach 1:
The traditional Chinese medicine formulation enhances the body's own metabolic capacity to regulate blood lipids. Ingredients like red yeast rice and tangshen stimulate endogenous enzymatic pathways and improve liver function, enabling the body to maintain lipid homeostasis independently, thereby reducing recurrence after treatment cessation.
Solution Approach 2:
The patent promotes continuous improvement of metabolic function through natural ingredients that accumulate beneficial effects over time. The formulation addresses root causes of dyslipidemia rather than just suppressing symptoms, creating sustained therapeutic effects that persist beyond treatment duration.
3Reliability
If chemical lipid-lowering agents are used, then blood lipid levels are controlled, but ability to prevent vascular plaques is insufficient
Solution Approach 1:
The patent converts harmful lipid accumulation into beneficial effects by using ingredients that promote the breakdown and elimination of atherosclerotic plaques. Red yeast rice and other components not only prevent new plaque formation but also facilitate regression of existing plaques by modulating inflammatory pathways and enhancing macrophage activity.
Solution Approach 2:
The traditional Chinese medicine formulation performs multiple functions simultaneously: lowering blood lipids, preventing vascular plaque formation, and promoting plaque regression. Ingredients like pinellia and tangshen provide anti-inflammatory, antioxidant, and lipid-regulating effects that collectively address both risk factor management and direct plaque pathology.
Data Source
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AI summary
The present invention provides a traditional Chinese medicine composition, and a preparation method therefor and an application thereof. The traditional Chinese medicine composition in the present invention comprises the following raw medicines in parts by weight: 10-35 parts of root of Chinese thorowax, 5-25 parts of immature bitter orange, 3-20 parts of fresh root and rhizome of sorrel rhubarb, 3-20 parts of root of baikal skullcap, 3-20 parts of white peony root, 3-15 parts of dried ginger, 5-20 parts of leech, 3-20 parts of root of ural licorice, 3-20 parts of root pilose asiabell, 3-20 parts of rhizome of largehead atractylodes, and 3-25 parts of tuber of pinellia. The traditional Chinese medicine composition has excellent effects in lowering blood lipids and cholesterol levels, particularly in lowering blood triglyceride. The traditional Chinese medicine composition in the present invention also has excellent effects in slowing formation of atherosclerotic plaques, clearing the atherosclerotic plaques, and preventing and treating atherosclerosis.