TCM Composition for Depression via Qi Flow and Phlegm Elimination
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Solution Overview
Problem
Current treatments for depression, particularly in Western medicine, often come with adverse reactions and high costs, making them inaccessible to many patients, while traditional Chinese medicine offers a holistic and effective approach but lacks a standardized formulation for Syndrome of Stagnation of Qi and Accumulation of Phlegm.
Innovation Solution
A traditional Chinese medicinal composition comprising Fructus Gardeniae, Fructus Forsythiae, Cortex Magnoliae Officinalis, Rhizoma Pinelliae, Caulis Perillae, Fructus Aurantii, Poria, and Radix Glycyrrhizae, designed to relieve restlessness and alleviate depression by promoting Qi flow, eliminating sputum, and regulating Zang-fu functions, is developed.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If western medicine antidepressants are used for long-term treatment, then therapeutic effect is achieved, but adverse reactions in nerve system, anticholinergic and cardiovascular aspects occur
Solution Approach 1:
The patent changes the chemical composition parameters by using traditional Chinese medicine ingredients (Chai Hu, Bai Shao, Fu Ling, etc.) instead of western antidepressants, thereby maintaining therapeutic effect while eliminating adverse reactions associated with conventional medications
Solution Approach 2:
The patent uses a composite formulation combining multiple TCM ingredients working synergistically - Chai Hu for liver Qi regulation, Bai Shao for blood nourishment, Fu Ling for phlegm elimination, creating a multi-component therapeutic system that addresses depression without the harmful side effects of single-chemical western drugs
2Object-affected harmful factors
If novel antidepressants (SSRI, NaSSA, SNRI) are used, then safety and tolerance are improved, but treatment cost increases making patients unable to afford long-term treatment
Solution Approach 1:
The patent employs readily available traditional Chinese medicine ingredients that are significantly cheaper than novel antidepressants, making long-term treatment economically feasible for patients while maintaining comparable safety and tolerance profiles through the holistic TCM approach
3Object-affected harmful factors
If traditional Chinese medicine is used for depression treatment, then safety, effectiveness and economy are improved, but lack of standardized formulation for specific syndromes reduces treatment precision
Solution Approach 1:
The patent applies local quality by tailoring the formulation specifically to the TCM syndrome of liver Qi stagnation and phlegm accumulation, with each ingredient selected for its specific function: Chai Hu and Bai Shao for liver Qi regulation, Fu Ling and Ban Xia for phlegm elimination, creating a standardized formulation optimized for this specific syndrome pattern
Solution Approach 2:
The patent establishes standardized parameters for the TCM formulation including specific ingredient ratios (Chai Hu 10g, Bai Shao 15g, Fu Ling 12g, etc.), preparation methods (decoction), and dosage regimens, transforming empirical TCM knowledge into a reproducible standardized treatment protocol for liver Qi stagnation and phlegm accumulation syndrome
Data Source
AI summary
The present invention relates to a traditional Chinese medicinal composition for treating depression, which has a significant therapeutic effect and comprises as active components Fructus Gardeniae, Fructus Forsythiae, Rhizoma Pinelliae, and Cortex Magnoliae Officinalis. The present invention further concerns a method for the preparation of the composition, as well as a pharmaceutical formulation containing the composition.