TCM Composition for Diabetic Retinopathy via Blood Circulation
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Solution Overview
Problem
Current treatments for diabetic retinopathy, particularly early stages and macular edema, lack standardized and systematic approaches, and existing therapies often fail to effectively address the underlying pathogenesis of 'deficiency in origin' and 'excess in superficiality' as described in traditional Chinese medicine, leading to inadequate management of symptoms and root causes.
Innovation Solution
A traditional Chinese medicine composition comprising Astragali Radix, Pseudostellariae Radix, Cinnamomi Ramulus, Angelicae Sinensis Radix, Notoginseng Radix ET Rhizoma, Dioscoreae Rhizoma, Salviae Miltiorrhizae Radix ET Rhizoma, Pheretima, Rehmanniae Radix, and Atractylodis Macrocephalae Rhizoma, which are combined and processed into various dosage forms to activate blood circulation, dissipate blood stasis, and nourish qi and yin, thereby addressing the pathogenic factors of diabetic retinopathy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional Chinese medicine is used to treat diabetic retinopathy, then visual acuity is improved and macular edema is reduced, but the treatment lacks standardized and systematic approaches
Solution Approach 1:
The TCM formula is segmented into specific herbs with defined weight ratios (Astragali Radix 30-60g, Pseudostellariae Radix 15-30g, Cinnamomi Ramulus 10-20g, Angelicae Sinensis Radix 20-40g, Notoginseng Radix ET Rhizoma 5-15g, Dioscoreae Rhizoma 30-60g, Salviae Miltiorrhizae Radix ET Rhizoma 20-40g, Pheretima 5-15g, Rehmanniae Radix 20-40g, Atractylodis Macrocephalae Rhizoma 10-20g), creating a standardized composition that addresses both symptom treatment and root cause while maintaining systematic structure
Solution Approach 2:
The treatment parameters are standardized by specifying exact weight ranges for each herb component, transforming the previously non-standardized TCM approach into a systematic treatment protocol with defined composition parameters that can be consistently manufactured and applied
2Reliability
If existing therapies are used, then treatment is provided, but they fail to effectively address the underlying pathogenesis of 'deficiency in origin' and 'excess in superficiality'
Solution Approach 1:
Different herbs are assigned specific functions targeting different aspects of the pathogenesis: Astragali Radix and Pseudostellariae Radix address qi deficiency (origin), while Notoginseng Radix ET Rhizoma and Salviae Miltiorrhizae Radix ET Rhizoma address blood stasis (superficiality), creating a treatment with differentiated local qualities that simultaneously address both deficiency and excess
Solution Approach 2:
The TCM composition integrates multiple therapeutic actions into a single formula that simultaneously nourishes qi and yin, activates blood circulation, dissipates blood stasis, and reduces edema, making it a universal treatment that addresses both the root cause (deficiency) and manifest symptoms (excess) of diabetic retinopathy
Data Source
AI summary
The present invention provides a traditional Chinese medicine (TCM) composition for the treatment of diabetic retinopathy, wherein the active pharmaceutical ingredients (APIs) of the said TCM composition are: Astragali Radix 10-80 parts by weight, Pseudostellariae Radix 5-30 parts by weight, Cinnamomi Ramulus 3-25 parts by weight, Angelicae Sinensis Radix 8-60 parts by weight, Notoginseng Radix ET Rhizoma 2-15 parts by weight, Dioscoreae Rhizoma 10-80 parts by weight, Salviae Miltiorrhizae Radix ET Rhizoma 10-80 parts by weight, Pheretima 2-15 parts by weight, Rehmanniae Radix 8-60 parts by weight, and Atractylodis Macrocephalae Rhizoma 8-60 parts by weight. It has been shown by clinical experiments that, the invented TCM composition has an exact efficacy in patients with macular edema and can effectively improve the patients' visual acuity and visual field and relieve ocular fundus diseases, playing an active role in alleviating macular edema.