TCM Compound for Diabetic Testicular Dysfunction via PI3K Pathway
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Solution Overview
Problem
Current treatments for testicular dysfunction in diabetic patients, particularly those with type 2 diabetes mellitus, are inadequate, as Western medicine often results in significant side effects and Traditional Chinese Medicine lacks an effective scheme for improving testicular dysfunction in obese type 2 diabetes.
Innovation Solution
A traditional Chinese medicine compound comprising Codonopsis pilosula, Astragalus membranaceus, Dioscorea opposita, Angelica sinensis, Atractylodes macrocephala, Poria cocos, Cynanchum otophyllum, Psoralea corylifolia, Ligusticum chuanxiong, Nelumbo nucifera, Euryale ferox, Amomum villosum, Alpinia katsumadai, Foeniculum vulgare, Cinnamomum cassia, Evodia ruticarpa, Piper nigrum, Zingiber officinale, and Glycyrrhiza uralensis, prepared through water extraction, which tonifies qi, nourishes yin, and regulates the male reproductive endocrine environment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Western medicine is used to treat T2DM, then blood sugar control is improved, but significant side effects occur
Solution Approach 1:
The patent changes the treatment approach from Western medicine to Traditional Chinese Medicine compound, altering the therapeutic parameters to achieve blood sugar control while reducing side effects through natural herbal components
Solution Approach 2:
The patent uses a composite TCM compound consisting of multiple herbal ingredients (Codonopsis pilosula, Astragalus membranaceus, Dioscorea opposita, and others) working synergistically to control blood sugar with fewer side effects compared to single-component Western medications
2Object-affected harmful factors
If Traditional Chinese Medicine is used to treat oligoasthenotspermia, then personalization and few side effects are achieved, but effective scheme for diabesity is not yet formed
Solution Approach 1:
The patent segments the treatment into specific functional groups of herbs: Codonopsis pilosula and Astragalus membranaceus for qi tonification, Dioscorea opposita for yin nourishment, and other herbs for specific therapeutic actions, creating a targeted formula for diabesity-related oligoasthenotspermia
Solution Approach 2:
The patent develops a composite TCM formula specifically designed for diabesity patients with oligoasthenotspermia, combining multiple herbs that work synergistically to address the complex pathogenesis of this condition, thereby forming an effective treatment scheme where none previously existed
3Reliability
If TCM compound is used to improve testicular dysfunction, then hormone secretion and semen parameters are improved, but treatment complexity increases
Solution Approach 1:
The patent creates a multi-functional TCM compound that simultaneously addresses multiple aspects of testicular dysfunction: improving hormone secretion (testosterone, FSH, LH), regulating reproductive endocrine environment, enhancing semen parameters (count, motility, morphology), and reducing oxidative stress, thereby simplifying treatment despite the complexity of the formula
Data Source
AI summary
A traditional Chinese medicine compound for improving testicular dysfunction is made from the following raw materials: Codonopsis pilosula, Astragalus membranaceus, Dioscorea opposita, Angelica sinensis, Atractylodes macrocephala, Poria cocos, Cynanchum otophyllum, Psoralea corylifolia, Ligusticum chuanxiong, Nelumbo nucifera, Euryale ferox, Amomum villosum, Alpinia katsumadai, Foeniculum vulgare, Cinnamomum cassia, Evodia ruticarpa, Piper nigrum, Zingiber officinale, Aconitum carmichaelii, and Glycyrrhiza uralensis. All the raw materials are combined, so that the spleen, the stomach and the kidney are in harmony, the qi, the blood and the body fluid are recovered, and the kidney essence is active. Animal experiments show that the traditional Chinese medicine compound can up-regulate expressions of phosphatidylinositol 3-kinase (PI3K), phospho-protein kinase B (p-AKT) and B-cell lymphoma-2 (Bcl-2), improve testicular dysfunction, improve hormone secretion, regulate a male reproductive endocrine environment of the body, and further improve semen parameters.