TCM Headache Composition Dual Solvent Extraction Method
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Solution Overview
Problem
Current methods for extracting active ingredients from Traditional Chinese Medicines (TCMs) for treating headache are inefficient, leading to incomplete extraction, low yield rates, and complications such as floating medicines and safety hazards, which affect the quality and efficacy of headache treatments.
Innovation Solution
A new pharmaceutical composition and preparation method involving separate extraction of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae alba, and Rhizoma Corydalis using ethanol refluxing, and Radix Rehmanniae Preparata, Ramulus Uncariae cum Uncis, Caulis Spatholobi, Spica Prunellae, Concha Margaritifera Usta, and Herba Asari using water decoction followed by ethanol precipitation, to produce a stable and effective headache treatment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If all TCMs are extracted together using a single method, then the extraction process is simple, but the extraction is incomplete and yield rate is low
Solution Approach 1:
The patent divides the extraction process into two separate segments: water extraction for water-soluble components and ethanol extraction for ethanol-soluble components. This segmentation allows each extraction method to be optimized for its target components, thereby improving overall extraction completeness and yield rate while maintaining process simplicity through systematic organization.
2Manufacturing precision
If ethanol is used for extracting all TCMs, then ethanol-soluble ingredients are well extracted, but water-soluble ingredients are not effectively extracted
Solution Approach 1:
The patent changes the extraction parameter (solvent type) to match the solubility characteristics of different TCM ingredients. Water extraction is applied for water-soluble components while ethanol extraction is used for ethanol-soluble components. This parameter adjustment ensures high extraction selectivity for each component type while maintaining broad applicability across diverse TCM materials.
3Manufacturing precision
If TCMs are extracted separately, then extraction completeness is improved, but the process complexity and operation difficulty increase
Solution Approach 1:
The patent merges the separately extracted water extract and ethanol extract into a single combined extract. This merging step consolidates the multiple extraction operations into one unified product, thereby improving extraction completeness through selective extraction while maintaining operational simplicity through the final combination step.
4Ease of manufacture
If traditional extraction methods are used, then the process is straightforward, but the treatment efficacy is slow and life quality is affected
Solution Approach 1:
The patent changes the extraction parameters (solvent types, extraction conditions) to optimize the extraction efficiency and bioavailability of active ingredients. This results in a more potent extract that acts faster, reducing treatment onset time while maintaining preparation simplicity through the systematic extraction protocol.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method enhances the extraction yield and stability of bioactive ingredients, improving the treatment efficacy for headache, traumatic cranial nerve syndrome, dizziness, vertigo, vexation, irritability, insomnia, and dreaminess, with demonstrated benefits in ameliorating cerebral pial microcirculation and pain relief.
Implementation Method 1
extracted by using heating refluxing with ethanol
Implementation Method 2
main ingredients of Radix Angelicae Sinensis (Dang gui) and Rhizoma Chuanxiong (Chuan xiong) are ethanol soluble
Implementation Method 3
decocted with water
Implementation Method 4
the Ramulus Uncariae cum Uncis contains a variety of indole alkaloids... Its water decoction and extract are proved to have significantly bio-active effects
Implementation Method 5
the extract is mixed with excipients to prepare into various kinds of pharmaceutical formulations... added with 2 fold of ethanol to leave it to stand still for 24 hours to precipitate
Data Source
AI summary
A pharmaceutical composition for treating headache, prepared from eleven Chinese herbal medicines: Chinese angelica root, ligusticum chuanxiong, radix paeoniae lactiflorae, prepared rhizome of rehmannia, uncaria tomentosa, leatherleaf milletia, prunella vulgaris, sicklesenna seed, pearl shell, corydalis tuber, and asarum, and a proper amount of adjuvant materials. A preparation method of the pharmaceutical composition, and uses thereof in the preparation of drugs for treating various headaches, traumatic cranial nerve syndrome, dizziness and vertigo, vexation and irritability, insomnia and dreaminess.