Cross-Linked Telechelic Polymer Dressings for Fast Skin Cure
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Solution Overview
Problem
Existing silicone skin-adhesive compositions face issues such as user application errors, poor organoleptic qualities, lengthy cure times, poor durability, and short shelf-life, limiting their commercial presence in dermatological products.
Innovation Solution
Development of cross-linked telechelic polymer compositions comprising specific polysiloxanes and transition metal catalysts, which form multilayered adhesive dressings with independent optimization of adhesivity and mechanical robustness through separate adhesive base and mechanical reinforcing layers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If in situ cross-linked polysiloxane films are used, then skin benefits such as skin cosmesis and reduction in skin trans-epidermal water loss are provided, but the film cure times are inconveniently lengthy
Solution Approach 1:
The patent modifies the chemical parameters of the polysiloxane system by introducing specific functional groups (vinyl, hydride, alkenyl) and catalysts to accelerate the cross-linking reaction rate, thereby reducing cure time while maintaining skin benefits
Solution Approach 2:
The patent replaces slow natural curing mechanisms with catalyzed chemical reactions, using transition metal catalysts to accelerate the cross-linking process and achieve rapid in situ curing
2Reliability
If in situ cross-linked polysiloxane films are used, then skin benefits are provided, but the shelf-life and storage stability are poor
Solution Approach 1:
The patent divides the polysiloxane system into separate functional components (adhesive base with vinyl groups, mechanical reinforcing layer with hydride groups, and catalysts) that remain stable during storage but react when applied to the skin, thereby extending shelf-life while maintaining skin benefits
Solution Approach 2:
The patent introduces catalysts as intermediary substances that remain dormant during storage but activate the cross-linking reaction upon application, enabling delayed curing that improves both shelf-life and skin benefits
3Loss of time
If cross-linked telechelic polymer compositions are used, then rapid in situ curing is achieved, but the device complexity increases due to multiple components
Solution Approach 1:
The patent combines multiple functional components (adhesive base, mechanical reinforcing layer, and catalysts) into an integrated multilayered composition that achieves rapid curing while managing complexity through coordinated design of interacting layers
4Strength
If cross-linked telechelic polymer compositions are used, then mechanical durability is improved, but the organoleptic qualities become poor
Solution Approach 1:
The patent applies different functional characteristics to different layers: the adhesive base provides skin adhesion and flexibility, while the mechanical reinforcing layer provides durability, with each layer's properties locally optimized to balance organoleptic qualities and mechanical performance
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The multilayered adhesive dressings provide consistent user application, favorable organoleptic characteristics, rapid in situ curing, and prolonged shelf-life stability, while ensuring mechanical durability and adhesiveness.
Implementation Method 1
cross-linked reaction product of any of: (i) at least one polysiloxane (a) comprising a number of diorganosiloxy monomers, at least one 1-alkenyl-1-organosiloxy monomer... and at least one Group X transition metal catalyst
Data Source
AI summary
The present disclosure relates, in part, to cross-linked telechelic polymer compositions and methods of preparation thereof. In another aspect, the present disclosure relates to multilayer compositions comprising an adhesive base (AB) and a mechanically reinforcing composition (MRC), methods of preparation thereof, and methods of use thereof. In certain embodiments, the in situ prepared compositions are suitable for application to the skin of a subject for treating a wound and/or skin condition.