Tembotrione Crystal Form D for Chemical Stability in Long-Term Storage
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Solution Overview
Problem
Existing crystal forms of tembotrione lack stability and solubility properties suitable for long-term storage and effective herbicidal application.
Innovation Solution
A novel crystal form D of tembotrione with higher melting point, better chemical stability, and slow dissolution rate is developed through crystallization in specific organic solvents, confirmed by X-ray powder diffraction and differential thermogravimetry.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If crystalline forms are used for long-term storage, then stability is improved, but solubility deteriorates
Solution Approach 1:
The patent applies parameter changes by systematically varying crystallization conditions (solvent type, temperature, pH, concentration) to produce different crystal forms with distinct properties. Crystal form D was obtained by crystallizing from specific solvents at controlled temperatures, resulting in a crystal structure with higher melting point and improved stability while maintaining controlled solubility characteristics.
2Speed
If amorphous forms are used for administration, then dissolution rate is improved, but stability deteriorates
Solution Approach 1:
The patent utilizes phase transitions by controlling the transition from amorphous to crystalline states through controlled crystallization processes. By adjusting crystallization parameters (temperature, solvent, cooling rate), the patent produces crystal form D with specific dissolution characteristics suitable for herbicidal application while ensuring long-term storage stability.
3Temperature
If higher melting point crystal forms are developed, then thermal stability is improved, but processing difficulty increases
Solution Approach 1:
The patent applies preliminary action by performing controlled crystallization during the manufacturing process to directly produce the desired crystal form D with high melting point. By pre-establishing optimal crystallization conditions (solvent selection, temperature profile, pH control), the patent achieves both thermal stability and manufacturing feasibility without requiring additional post-processing steps.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The novel crystal form D provides enhanced stability and reduced solubility, making it suitable for long-term storage and effective herbicidal use with improved chemical properties.
Implementation Method 1
X-ray powder diffraction pattern (Figure 1) recorded with Cu-Kα radiation (1.54443Å) at 25°C shows characteristic reflections represented by 2θ degree or interplanar spacing d (d[Å])
Implementation Method 2
X-ray powder diffraction method basing on the diffraction pattern thereof
Implementation Method 3
differential thermogravimetry was also used. The melting point of the novel crystal form of tembotrione was tested with initial temperature of 60°C, the temperature rising to 180°C at a speed of 10°C/min
Data Source
Figure 1
AI summary
The invention belongs to the field of chemical synthesis and discloses a new crystal form of tembotrione, which is a herbicide, a preparation method thereof, and an application thereof as a preparation for plant protection. The present invention obtains a previously unknown, stable, new crystal form D of tembotrione by a suitable method and overcomes the disadvantages of amorphous tembotrione. The crystal form D has a crystal structure completely different from three crystal forms A, B and C reported in WO08110621A, and thus fills a gap in national patent protection of this technology. Compared with tembotrione in other crystal forms, tembotrione in crystal form D has the advantages of a higher melting point, better chemical stability, lower dissolution rate, reduced solubility, and is thus suitable for long-term storage. The crystal structure is highly suitable for storing a tembotrione compound.