Temperature-Compensated Drug Delivery Apparatus

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Solution Overview

Problem

Existing drug delivery systems lack the ability to autonomously deliver medications to unskilled and unsupervised recipients at a variable rate, particularly in scenarios where temperature fluctuations affect the viscosity of the drug and battery performance, leading to potential pain and mechanical issues during injection.

Innovation Solution

A portable, temperature-sensitive drug delivery apparatus that includes a processor-controlled discharge mechanism, which waits for a predetermined time after activation to initiate delivery and adjusts the delivery rate based on temperature readings, allowing for a variable rate schedule that can be adjusted by the recipient to minimize pain and ensure optimal delivery conditions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Loss of time

If the drug is delivered immediately after activation, then the delivery time is reduced, but the drug viscosity may be too high due to low temperature, causing mechanical stress and pain

Engineering Contradiction:
Improvedelivery timeVSAvoidpain and mechanical stress
Core Design Contradiction:
Loss of timeVSObject-affected harmful factors

Solution Approach 1:

The processor waits for a predetermined time period after activation before initiating drug delivery. This preliminary waiting period allows the drug to warm up to a suitable temperature, reducing its viscosity and preventing pain and mechanical stress during injection, while still maintaining relatively quick overall delivery time

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The temperature sensor continuously monitors the drug temperature and provides feedback to the processor. The processor uses this feedback to determine when the drug has reached a suitable temperature for delivery, dynamically adjusting the waiting period based on actual temperature conditions rather than using a fixed delay

Inventive Principle:
Principle #23Feedback

2Productivity

If the delivery rate is increased to reduce treatment time, then productivity is improved, but the pain and mechanical stress increase

Engineering Contradiction:
Improvedelivery rateVSAvoidpain and mechanical stress
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The discharge mechanism operates at variable rates rather than a fixed rate. The processor can adjust the delivery rate dynamically based on temperature feedback, starting at lower rates when the drug is colder and more viscous, and potentially increasing rates as the drug warms up, thereby maintaining productivity while reducing pain and mechanical stress

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The system changes the delivery rate parameter based on temperature conditions. By monitoring temperature and adjusting the delivery rate accordingly, the system optimizes the balance between productivity and patient comfort, delivering the drug efficiently when conditions are favorable and slowing down when viscosity is high

Inventive Principle:
Principle #35Parameter changes

3Device complexity

If the apparatus operates without temperature compensation, then device complexity is reduced, but the delivery reliability deteriorates due to temperature-dependent viscosity changes

Engineering Contradiction:
Improvetemperature control mechanismVSAvoiddelivery reliability
Core Design Contradiction:
Device complexityVSReliability

Solution Approach 1:

A temperature sensor provides continuous feedback on the drug temperature to the processor. This feedback mechanism allows the system to automatically compensate for temperature-dependent viscosity changes, ensuring reliable delivery by adjusting the waiting period and delivery rate based on actual temperature conditions without requiring complex manual intervention

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The system performs self-adjustment based on temperature feedback. The processor automatically determines the appropriate waiting period and delivery parameters by monitoring temperature itself, eliminating the need for external temperature control mechanisms or manual adjustment by the user, thus maintaining simplicity while improving reliability

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables safe, efficient, and pain-reduced drug delivery to unskilled recipients, ensuring the drug is delivered at a suitable temperature, thereby reducing mechanical stress on the apparatus and improving patient comfort, while allowing for autonomous operation without supervision.

Implementation Method 1

A temperature sensor is configured to sense a temperature of one of a component of the apparatus or the drug

Methodology Applied
Scientific EffectTemperature sensing:

Implementation Method 2

The processor is programmed to wait a predetermined period of time after activation before initiating the delivery of the drug, and is further configured to adjust the waiting time based on the temperature sensed by the temperature sensor

Methodology Applied
Scientific EffectTemperature-dependent viscosity adjustment:

Implementation Method 3

The processor is configured to control the discharge mechanism and to adjust a rate of delivery of the drug according to the temperature sensed by the temperature sensor

Methodology Applied
Scientific EffectTemperature-dependent flow rate control:

Data Source

PatentEP2809375B1Time dependent drug delivery apparatus
Publication Date: 2021.08.11 MEDIMOP MEDICAL PROJECTS
  • EP2809375B1 patent drawingFigure 1a~1c
  • EP2809375B1 patent drawingFigure 2
  • EP2809375B1 patent drawingFigure 3a~3b

AI summary

An apparatus are disclosed for autonomous variable rate delivery of a substance. In some embodiments, the delivery apparatus may be programmable. In some embodiments, the delivery apparatus may be disposable. Optionally the rate of delivery may be dependent on a temperature of a component of the apparatus. Optionally, there may be a time delay between activation of the apparatus and delivery of the substance.