Temperature-Compensated In-Vivo Sensor Assembly
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Solution Overview
Problem
Current glucose monitoring devices face challenges in accurately measuring blood glucose levels due to temperature fluctuations, which can lead to significant measurement errors, and require complex procedures and specialized equipment for sensor placement and calibration.
Innovation Solution
A temperature-compensated in-vivo biosensor assembly with a sensor sheath containing analyte and temperature sensor elements, designed for use with commercially available catheters, which includes a temperature sensor element to accurately measure and compensate for temperature changes, ensuring precise glucose monitoring without the need for specialized techniques or equipment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a biosensor is used to measure analyte concentration in body fluid, then measurement capability is provided, but temperature fluctuations cause measurement errors and reduce measurement precision
Solution Approach 1:
The patent implements a feedback mechanism by continuously monitoring temperature with a temperature sensor element and using this information to compensate for temperature-induced measurement errors in the analyte sensor. The system measures temperature, calculates the temperature effect on the analyte measurement, and adjusts the reading accordingly, creating a closed-loop compensation system that maintains measurement precision despite temperature variations.
Solution Approach 2:
The patent applies parameter changes by measuring the temperature parameter and using it to adjust the analyte concentration measurement. The system changes the measurement parameter from a simple analyte reading to a temperature-compensated analyte reading, where the compensation factor is derived from the measured temperature. This allows the system to adapt to varying temperature conditions and maintain accurate measurements.
2Reliability
If specialized equipment and complex procedures are used for sensor placement and calibration, then measurement reliability is improved, but device complexity and ease of operation deteriorate
Solution Approach 1:
The patent merges the temperature sensing function with the analyte sensing function into a single integrated sensor assembly. Both sensor elements are positioned in close proximity within the same housing, allowing simultaneous measurement of temperature and analyte concentration. This integration eliminates the need for separate temperature monitoring equipment and simplifies the overall system while maintaining measurement reliability.
Solution Approach 2:
The system performs self-calibration and self-compensation by using the temperature sensor to automatically adjust for temperature effects on the analyte measurement. The microprocessor automatically calculates compensation factors and adjusts readings without requiring manual calibration procedures or specialized equipment, making the system easier to operate while maintaining reliability.
3Measurement precision
If temperature compensation is implemented, then measurement precision under varying temperature conditions is improved, but device complexity increases
Solution Approach 1:
The patent employs a nested structure where the temperature sensor element is positioned within or adjacent to the analyte sensor element, both housed within the same sensor housing. This nested arrangement allows compact integration of multiple sensing functions without significantly increasing the overall device size or structural complexity, while enabling temperature compensation to improve measurement precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biosensor assembly provides accurate and reliable glucose measurements by compensating for temperature fluctuations, improving usability and reducing the complexity of procedures, and ensuring accurate analyte concentration readings even in varying temperature conditions.
Implementation Method 1
a temperature sensor element for determining a temperature of a body fluid in contact with the analyte sensor element
Implementation Method 2
an analyte sensor element for generating a signal in response to an analyte concentration in a body fluid
Data Source
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AI summary
An in-vivo sensor assembly includes an assembly body having a body proximal end and a body distal end, a plurality of sensor elements including at least an analyte sensor element containing an enzyme that is a substrate of the analyte to be measured, a reference sensor element and a temperature sensor element disposed at or near the body distal end wherein the at least an analyte sensor element and the reference sensor element are exposed to the sample fluid and the temperature sensor is capable of measuring the temperature of and adjacent to the analyte sensor element, and an electrical coupling means disposed at the body proximal end and configured to couple to the at least an analytical sensor element, the reference sensor element and the temperature sensor element.