Method for determining the presence of an analyte
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Solution Overview
Problem
Existing methods for determining the presence of an analyte in a sample are inaccurate and prone to false positives or negatives, especially in uncontrolled environments where temperature fluctuations affect voltammetric signals, and interferants complicate signal recognition.
Innovation Solution
A method involving the selection of reference voltage ranges associated with specific temperature ranges, allowing for accurate detection of analyte signals by measuring voltammetric responses across these ranges, irrespective of temperature variations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If voltammetric measurement is performed in uncontrolled environments with temperature variations, then portability and immediate detection capability are improved, but measurement precision deteriorates due to temperature-dependent signal shifts
Solution Approach 1:
The patent applies parameter changes by using multiple reference voltage ranges that are specifically associated with different temperature ranges. Instead of attempting to control the temperature, the system adapts to temperature variations by selecting the appropriate reference voltage range based on the measured sample temperature, thereby maintaining measurement precision across varying environmental conditions
Solution Approach 2:
The patent implements dynamics by making the reference voltage range selection dynamic rather than static. The system continuously monitors the sample temperature and dynamically selects the most appropriate reference voltage range from multiple pre-defined ranges, allowing the detection system to adapt in real-time to changing environmental conditions
2Device complexity
If a single reference voltage range is used for analyte detection, then device complexity is reduced, but reliability deteriorates due to false positives and false negatives caused by temperature-induced signal shifts
Solution Approach 1:
The patent applies segmentation by dividing the single reference voltage range into multiple distinct reference voltage ranges, each associated with a specific temperature range. This segmentation allows the system to match the appropriate reference range to the measured temperature, improving detection reliability without requiring complex additional hardware
Solution Approach 2:
The patent implements preliminary action by pre-defining multiple reference voltage ranges and their associated temperature ranges before actual analyte detection. This preparatory work allows the system to quickly select the appropriate reference range based on measured temperature, avoiding the need for complex real-time calculations during detection
3Measurement precision
If multiple reference voltage ranges are used to account for temperature variations, then measurement precision is improved across varying temperatures, but device complexity increases
Solution Approach 1:
The patent manages the increase in complexity by systematically organizing multiple reference voltage ranges with their associated temperature ranges. The method complexity is justified by the significant improvement in measurement precision across varying temperatures, and the complexity is minimized through automated temperature-based selection logic
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise and rapid analyte detection with reduced false positives/negatives across varying temperatures and interferant conditions, without the need for laboratory transfer.
Implementation Method 1
a compound, such as an analyte, may have a well-defined voltammetric signal, for example at which the analyte is oxidized or reduced
Implementation Method 2
a compound, such as an analyte, may have a well-defined voltammetric signal, for example at which the analyte is oxidized or reduced
Implementation Method 3
measuring a voltammetric response of the sample
Data Source
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AI summary
Method for determining the presence of an analyte in a sample at a sample temperature comprising: selecting a reference voltage range amongst at least a first reference voltage range and a second reference voltage range, wherein the selected reference voltage range is associated with a temperature range in which the sample temperature falls, wherein the first reference voltage range is associated with a first temperature range and the second reference voltage range is associated with a second temperature range, each reference voltage range comprising a plurality of different voltage values at which a voltammetric signal of the analyte can be detected at a temperature falling in the temperature range associated with the reference voltage range; measuring a voltammetric response of the sample across the selected reference voltage range; determining whether the analyte is present in the sample by analyzing whether the voltammetric signal can be detected in the voltammetric response.