Temperature-Sensitive Composite for Sustained Drug Release

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Solution Overview

Problem

Existing temperature-sensitive drug delivery systems are unstable in aqueous solutions, leading to fast drug release and requiring repeated administration, especially for water-soluble drugs or proteins, which increases treatment costs and reduces efficacy.

Innovation Solution

A temperature-sensitive composite comprising nanoparticles with a biocompatible polymer exhibiting a temperature-induced phase transition and a drug, combined with a diluent, which maintains stability and redispersibility in aqueous solutions, allowing for controlled drug release.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If a temperature-sensitive polymer-based drug delivery system is used, then the system can maintain liquid state at room temperature and solidify at body temperature, but the system exhibits fast drug release and instability when administered, requiring repeated administration

Engineering Contradiction:

Improveliquid state at room temperature for injectionVSAvoiddrug release stability

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent combines temperature-sensitive polymer (Pluronic F-127) with temperature-insensitive polymer (sodium hyaluronate) to create a composite hydrogel system. This composite structure maintains the temperature-responsive gelation capability while the sodium hyaluronate provides structural stability and controls drug release kinetics, preventing premature disintegration and fast release

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent optimizes the concentration ratio of Pluronic F-127 to sodium hyaluronate to achieve desired gel strength and drug release profile. By adjusting polymer concentrations and molecular weights, the system maintains stability in aqueous environment while preserving temperature-induced phase transition capability

Inventive Principle:

Principle #35Parameter changes

2Ease of manufacture

If water-soluble drugs or proteins are contained in the delivery system, then the drugs can be easily administered, but fast drug release is induced due to excellent solubility in aqueous solution, reducing efficacy

Engineering Contradiction:

Improveeasy formulation of water-soluble drugsVSAvoiddrug release duration

Core Design Contradiction:

Ease of manufactureVSDuration of action of stationary object

Solution Approach 1:

The patent creates a heterogeneous hydrogel matrix where sodium hyaluronate forms a stable three-dimensional network structure that locally traps water-soluble drugs. This local entrapment within the polymer matrix prevents rapid diffusion into surrounding aqueous environment, extending drug release duration while maintaining ease of formulation

Inventive Principle:

Principle #3Local quality

3Reliability

If repeated administration is required to maintain efficacy, then treatment stability can be maintained, but treatment cost increases for expensive protein drugs or antibodies

Engineering Contradiction:

Improvetreatment efficacy stabilityVSAvoidtotal drug dosage required

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent designs a sustained-release hydrogel system that continuously releases drugs over extended periods (days to weeks). The interconnected polymer network structure and gel matrix provide prolonged drug reservoir, maintaining therapeutic levels continuously and eliminating the need for frequent re-administration, thereby reducing total drug consumption

Inventive Principle:

Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composite achieves sustained drug release and improved stability, enabling effective delivery of both hydrophobic and water-soluble drugs, reducing the need for repeated administration and enhancing treatment efficacy.

Implementation Method 1

nanoparticles including a biocompatible polymer exhibiting a temperature-induced phase transition and a drug

Methodology Applied

Scientific EffectTemperature-induced phase transition: Phase Change

Data Source

PatentUS10744092B2Temperature-sensitive composite and method for preparing same

Publication Date: 2020.08.18 MIRACLES CORP

AI summary

The present invention relates to a temperature-sensitive composite and a method for preparing the same. The temperature-sensitive composite according to the present invention is maintained in a liquid state at room temperature and solidified at the time of delivery in the body, and shows remarkably excellent improvement in mechanical properties compared with an existing temperature-sensitive polymer composite, and as a result, the temperature-sensitive composite can promote the stability of a drug delivery system in the body and the sustainment of drug release.