Terminal-Modified Peptide for Skin Penetration and Stability
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Solution Overview
Problem
Existing peptides for skin improvement face challenges such as poor tissue penetration and short half-life, limiting their effectiveness in promoting collagen synthesis, fibroblast proliferation, and antioxidant activity, thus failing to adequately address skin aging and damage.
Innovation Solution
A peptide with a specific amino acid sequence (SEQ ID NO: 1) is synthesized with chemical modifications for enhanced stability and specificity, formulated into cosmetic and pharmaceutical compositions to improve skin health by promoting collagen synthesis, fibroblast proliferation, and antioxidant activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional peptides are used for skin improvement, then collagen synthesis and fibroblast proliferation are promoted, but tissue penetration is poor and half-life is short
Solution Approach 1:
The patent applies parameter changes by modifying the peptide's chemical structure through specific amino acid sequence design (SEQ ID NO: 1) and terminal modifications (acetylation at N-terminus, amidation at C-terminus). These structural parameter changes enhance the peptide's stability and penetration capability while maintaining its bioactivity in promoting collagen synthesis and fibroblast proliferation.
Solution Approach 2:
The patent creates a composite structure by combining the active peptide sequence with protective terminal groups (acetyl and amide modifications). This composite design protects the peptide from degradation while facilitating skin penetration, thereby resolving the contradiction between short half-life and therapeutic effectiveness.
2Duration of action of stationary object
If peptide structure is modified for enhanced stability, then half-life is extended, but manufacturing complexity increases
Solution Approach 1:
The patent employs parameter changes through targeted chemical modifications at the peptide terminals (acetylation and amidation). These modifications are implemented using standard peptide synthesis techniques, extending half-life without requiring complex manufacturing processes. The solution balances stability enhancement with manufacturing feasibility.
3Object-affected harmful factors
If existing peptides are applied to skin, then some antioxidant activity is achieved, but oxidative stress reduction is insufficient
Solution Approach 1:
The patent applies parameter changes by optimizing the peptide's amino acid sequence (SEQ ID NO: 1) to enhance its antioxidant properties. The specific sequence configuration improves the peptide's ability to scavenge reactive oxygen species and reduce oxidative stress in skin cells, achieving superior antioxidant effectiveness compared to conventional peptides.
Data Source
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Figure 3A~3C
AI summary
The present application relates to a peptide having the activity of improving the state of skin, and uses thereof, and provides a peptide consisting of an amino acid sequence of SEQ ID NO: 1, and a cosmetic composition for improving the state of skin, including, as an active ingredient, the peptide consisting of the amino acid sequence of SEQ ID NO: 1.