3D Terry Fabric Cardiac Patch for Myocardium Regeneration
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current cardiac patches and therapies for myocardial regeneration lack mechanical properties similar to those of natural cardiac muscle, leading to inadequate cell survival, proliferation, and integration, as well as insufficient mechanical support for damaged heart tissue.
Innovation Solution
Development of three-dimensional terry fabrics using biocompatible yarns that mimic the mechanical properties of cardiac muscle, providing a scaffold for cell attachment, growth, and proliferation, while offering additional surface area and pore structure for enhanced cell migration and attachment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If conventional cardiac patches are used, then mechanical support is provided, but mechanical properties similar to natural cardiac muscle are not achieved
Solution Approach 1:
The patent employs a porous scaffold structure that mimics the natural extracellular matrix of cardiac tissue. This porous architecture provides both mechanical support and facilitates cell infiltration, nutrient transport, and waste removal, thereby achieving mechanical properties similar to natural cardiac muscle while supporting cell survival and integration.
Solution Approach 2:
The patent utilizes composite materials combining biodegradable polymers with bioactive components to create a scaffold that replicates the mechanical properties of native cardiac tissue. The composite structure provides appropriate stiffness, elasticity, and degradation characteristics while supporting cell attachment and proliferation.
2Reliability
If cell-based therapies are used, then heart function restoration is aimed, but cell survival rate is very low
Solution Approach 1:
The patent prepares a pre-formed scaffold with optimized mechanical properties and porous structure before cell implantation. This preliminary preparation creates a favorable microenvironment that protects injected cells from mechanical stress and promotes their survival, addressing the low cell survival rate issue while maintaining the goal of heart function restoration.
Solution Approach 2:
The scaffold acts as an intermediary between the injected cells and the host tissue environment. It provides mechanical support, facilitates nutrient and oxygen transport, and promotes cell-cell interactions, thereby improving cell survival rates while aiming to restore heart function.
3Reliability
If natural biomaterials are used, then cell adhesion and proliferation are increased, but mechanical properties and reproducibility are poor
Solution Approach 1:
The patent combines natural biomaterials with synthetic polymers to create composite scaffolds that exhibit both excellent cell adhesion properties (from natural materials) and superior mechanical strength and reproducibility (from synthetic components). This composite approach resolves the contradiction between biological activity and mechanical performance.
Solution Approach 2:
The patent modifies the physical and chemical parameters of biomaterials through controlled degradation, crosslinking, and compositional adjustments to achieve optimal balance between cell adhesion/proliferation and mechanical properties. The material parameters are tuned to match native cardiac tissue characteristics while maintaining reproducibility.
Data Source
AI summary
The present invention relates to a cardiac patch comprising three-dimensional terry fabric as scaffold material for use in myocardium regeneration. In addition, the present invention can also be used in tissue engineering and regenerative medicine.