Single Test Strip Simultaneous Glucose and Glycated Hemoglobin Detection
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Solution Overview
Problem
Conventional methods for detecting glucose concentration and glycated hemoglobin in diabetes management require separate tests, are inconvenient for patients, and involve large blood samples and complex reactions that need professional operation.
Innovation Solution
A test strip with a conductive layer and an electro-catalytic layer having a porous structure is used to simultaneously detect glucose concentration and glycated hemoglobin, allowing for direct injection of a blood sample without pretreatment, with specific voltage steps and electrochemical signal analysis to determine both parameters.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If separate detection methods are used for glucose concentration and glycated hemoglobin, then detection accuracy is maintained, but detection convenience and time efficiency deteriorate
Solution Approach 1:
The patent combines two separate detection functions (glucose concentration detection and glycated hemoglobin percentage detection) into a single test strip. The test strip contains multiple working electrodes with different catalytic materials that can simultaneously detect both analytes in one blood sample application, eliminating the need for separate tests and reducing detection time while maintaining accuracy through independent measurement channels.
Solution Approach 2:
The test strip is designed as a multi-functional device that can perform both glucose concentration detection and glycated hemoglobin percentage detection using a single blood sample. The universal design allows one test strip to replace multiple specialized test strips, improving convenience and reducing the time loss associated with sequential testing.
2Measurement precision
If conventional glycated hemoglobin detection is used, then detection accuracy is maintained, but operation complexity and professional personnel requirements increase
Solution Approach 1:
The test strip incorporates pre-loaded reagents and catalytic materials (such as ferricyanide and specific catalysts) that enable the detection process to proceed automatically once the blood sample is applied. The electrochemical reactions occur spontaneously under controlled conditions, eliminating the need for manual addition of reagents or complex operational steps, thereby simplifying the process for patient self-testing while maintaining detection accuracy.
Solution Approach 2:
The patent replaces complex mechanical or manual operations with electrochemical detection. Instead of requiring manual sample preparation, reagent addition, or complex processing steps, the system uses electrochemical signals generated by the interaction between the blood sample components and the catalytic materials on the test strip electrodes. This substitution simplifies the operation to merely applying the blood sample to the strip.
3Measurement precision
If conventional glycated hemoglobin detection is used, then detection accuracy is maintained, but blood sample volume requirement increases
Solution Approach 1:
The test strip combines multiple detection functions into a single measurement platform where both glucose and glycated hemoglobin are detected from the same blood sample aliquot. This merging approach allows efficient use of the blood sample volume, as the sample is distributed across multiple electrode sites on the strip simultaneously, reducing the total volume needed compared to sequential separate tests.
Solution Approach 2:
The test strip utilizes thin film structures for the electrochemical sensing layers, which require minimal sample volume for adequate reaction. The blood sample only needs to sufficiently wet the thin film electrode surfaces to enable detection, dramatically reducing the required blood sample volume compared to conventional methods that use larger reaction vessels or multiple separate test systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables quick and accurate simultaneous detection of glucose and glycated hemoglobin in under 30 seconds with minimal sample volume, reducing the need for complex procedures and professional personnel, enhancing patient convenience.
Implementation Method 1
The electro-catalytic layer includes a porous structure, and the electro-catalytic layer is for catalyzing long-chain biomacromolecules or short-chain biomacromolecules in a neutral environment
Implementation Method 2
A first detecting step is performed, wherein a first current signal value of the test strip is obtained at a first detecting potential at a first detection time point. A second detecting step is performed, wherein a background current signal value of the test strip is obtained at a second detecting potential
Data Source
AI summary
A test strip includes a working electrode including a conductive layer and an electro-catalytic layer deposited on the conductive layer. A method for simultaneously detecting a glucose concentration and a percentage of glycated hemoglobin in a single test strip includes following steps: providing a blood sample, providing the aforementioned test strip, performing a sample injecting step, performing an initial step, performing a first detecting step, performing a second detecting step, performing a third detecting step, performing a first analyzing step, and performing a second analysis step.