Test Vessel Pre-Heating Apparatus for Rapid Thermal Control

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Solution Overview

Problem

Conventional diagnostic systems lack effective sample temperature compensation, leading to variations in reaction kinetics and inaccurate test results due to inconsistent sample temperatures during incubation, which affects analytical testing throughput and accuracy.

Innovation Solution

A specimen testing apparatus with a test vessel pre-heating apparatus that includes a receptacle and at least one heating unit configured to heat the test vessel by direct contact, utilizing pliable thermally conductive insulators and Peltier heaters to achieve precise temperature control, allowing for efficient pre-heating before transferring the test vessel to an incubator.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional incubation heating is used without pre-heating, then the system structure remains simple, but sample temperature varies and reaction kinetics become inconsistent

Engineering Contradiction:
Improvetest result accuracyVSAvoidheating system complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The test vessel is pre-heated to the target temperature before the sample is added. This preliminary heating action ensures that when the sample enters the vessel, the temperature is already controlled, eliminating temperature variability during the critical reaction phase. The pre-heating step is performed in advance using a dedicated heating block with Peltier heaters, which then maintains consistent conditions during incubation.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The heating function is divided into separate components: a pre-heating block for initial temperature control and an incubation chamber for maintained heating. This segmentation allows each component to be optimized independently - the pre-heating block uses direct contact Peltier heaters for rapid temperature establishment, while the incubation chamber provides sustained thermal environment, thereby improving overall temperature control precision without requiring the entire system to be overly complex.

Inventive Principle:
Principle #1Segmentation

2Productivity

If manual temperature compensation is performed, then temperature control can be adjusted, but testing throughput decreases due to manual intervention

Engineering Contradiction:
Improvetesting throughputVSAvoidtemperature consistency
Core Design Contradiction:
ProductivityVSMeasurement precision

Solution Approach 1:

The system automatically performs temperature compensation through integrated temperature sensors and control circuits that monitor and adjust heating parameters without manual intervention. The microprocessor-controlled system self-regulates the Peltier heater output based on real-time temperature feedback, maintaining consistent sample temperature throughout the testing process. This automated self-service approach eliminates the need for manual temperature compensation while preserving testing throughput.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

Temperature sensors continuously monitor the sample temperature in the test vessel, and this feedback is fed to the control system which adjusts the Peltier heater power accordingly. This closed-loop feedback mechanism ensures that temperature variations are automatically compensated in real-time, maintaining measurement precision while allowing continuous automated operation that preserves high testing throughput.

Inventive Principle:
Principle #23Feedback

3Loss of time

If rapid heating is implemented using direct contact heating, then incubation time is reduced, but heat distribution uniformity may be compromised

Engineering Contradiction:
Improveincubation timeVSAvoidtemperature uniformity
Core Design Contradiction:
Loss of timeVSStability of the object's composition

Solution Approach 1:

Multiple Peltier heaters are positioned at different locations within the heating block to provide localized heating zones. Each heater can be independently controlled to ensure uniform heat distribution across the entire sample area. This local quality approach allows rapid heating while preventing hot spots or uneven temperature distribution, as each region receives appropriate thermal energy independently.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The heating block utilizes composite construction with thermally conductive materials that facilitate rapid and uniform heat distribution. The combination of high-conductivity base materials with strategically positioned Peltier heaters creates an efficient thermal pathway network that quickly equilibrates temperature throughout the sample volume, achieving both rapid heating and temperature uniformity simultaneously.

Inventive Principle:
Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This solution ensures consistent sample temperatures, reduces incubation time, increases testing accuracy and throughput, and decouples patient sample and reaction vessel temperature variability, thereby improving overall diagnostic efficiency and reducing costs.

Implementation Method 1

utilizing pliable thermally conductive insulators and Peltier heaters to achieve precise temperature control

Methodology Applied
Scientific EffectPeltier effect: Peltier Effect

Implementation Method 2

at least one heating unit configured to heat by direct contact a side of the test vessel

Methodology Applied
Scientific EffectThermal conduction: Conduction (thermal)

Data Source

PatentEP3621738B1Methods and apparatus for rapid heating of biological specimens
Publication Date: 2024.01.17 SIEMENS HEALTHCARE DIAGNOSTICS INC
  • EP3621738B1 patent drawingFigure 1
  • EP3621738B1 patent drawingFigure 2A~2B
  • EP3621738B1 patent drawingFigure 2C

AI summary

Methods of pre-heating a test vessel prior to transfer of the test vessel to an incubator may shorten an incubation cycle, ensure proper temperature of a test specimen in the test vessel, and/or improve testing accuracy and/or throughput in a bio-liquid specimen testing apparatus. The methods include providing a test vessel pre-heating apparatus having a receptacle sized to receive a test vessel therein and having at least one heating unit configured to heat by direct conduction at least one side of the test vessel. The methods also include heating at least one side of the test vessel via direct contact using the at least one heating unit. Specimen testing apparatus and test vessel pre-heating apparatus configured to carry out the method are described, as are other aspects.