Powered Testosterone Injection for Low Leak-Back Delivery

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Solution Overview

Problem

Conventional methods of administering testosterone, such as hypodermic injections and transdermal creams/gels, are painful, inconvenient, and lead to issues like polycythemia, skin irritation, and inadequate testosterone levels, necessitating a more effective and comfortable delivery method.

Innovation Solution

The use of powered injectors, including autoinjectors and needle-free jet injectors, that administer testosterone formulations quickly and efficiently with minimal leak-back, utilizing high pressure and speed to deliver the medication as a fluid jet, reducing the need for manual force and minimizing exposure.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If hypodermic injections are used to administer testosterone, then the medication can be delivered effectively, but the procedure becomes painful and increases the risk of polycythemia

Engineering Contradiction:

Improvemedication delivery effectivenessVSAvoidpain and polycythemia risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the traditional mechanical hypodermic injection system with a jet injection system that uses high-pressure fluid dynamics to deliver testosterone. The jet injector propels the medication through a fine jet of liquid at high velocity, eliminating the need for needle penetration and manual injection mechanics, thereby reducing pain and tissue trauma while maintaining effective drug delivery

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent employs pneumatic and hydraulic principles by using high-pressure gas or liquid to propel the testosterone medication through a nozzle as a focused jet. This hydraulic/pneumatic propulsion system replaces mechanical syringe-based injection, enabling painless delivery while controlling the depth and distribution of medication penetration to avoid polycythemia risks associated with intramuscular injection

Inventive Principle:

Principle #29Pneumatics and hydraulics

2Ease of operation

If transdermal creams, gels and patches are used to administer testosterone, then the administration is convenient, but they cause acne and skin irritation and have poor compliance

Engineering Contradiction:

Improveadministration convenienceVSAvoidacne and skin irritation

Core Design Contradiction:

Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the transdermal application system (creams, gels, patches) with a jet injection system that delivers medication directly into the subcutaneous tissue. This substitution eliminates prolonged skin contact that causes irritation and acne, while the rapid jet injection maintains convenience by requiring minimal patient effort and providing quick administration

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces a fine jet of liquid as an intermediary medium to deliver testosterone directly into the tissue without requiring the medication to remain in contact with the skin surface. This intermediary jet delivery method bypasses the skin irritation issues associated with transdermal creams and patches while maintaining ease of administration

Inventive Principle:

Principle #24Intermediary (Mediator)

3Device complexity

If manual injection methods are used, then the equipment is simple, but they require significant manual force and result in leak-back

Engineering Contradiction:

Improveequipment simplicityVSAvoidmanual force requirement and leak-back

Core Design Contradiction:

Device complexityVSForce

Solution Approach 1:

The patent uses pneumatic or hydraulic pressure systems to propel the testosterone medication through the injection needle as a high-velocity jet. This pressure-driven system replaces manual pushing force, eliminating leak-back by ensuring complete medication delivery through the needle, while the automated pressure application reduces device complexity by using simple pressure tanks or springs rather than complex pumping mechanisms

Inventive Principle:

Principle #29Pneumatics and hydraulics

Solution Approach 2:

The patent employs periodic or pulsed pressure application to deliver the medication in a controlled jet manner. The intermittent high-pressure pulses propel the medication through the needle efficiently, reducing the need for continuous manual force while preventing leak-back through controlled delivery timing and pressure modulation

Inventive Principle:

Principle #19Periodic action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution provides steady state blood concentration of testosterone with reduced leak-back, improved compliance, and enhanced patient comfort by delivering the medication rapidly and effectively, minimizing skin exposure and ensuring the entire dose reaches the desired depth.

Implementation Method 1

utilizing high pressure and speed to deliver the medication as a fluid jet

Methodology Applied

Scientific EffectFluid jet injection: Jet

Implementation Method 2

utilizing high pressure and speed to deliver the medication as a fluid jet

Methodology Applied

Scientific EffectHigh pressure injection: Pressure Increase

Data Source

PatentUS12527802B2Administration of testosterone compositions

Publication Date: 2026.01.20 ANTARES PHARMA INC

AI summary

The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.