Tethered Basket Embolus Capture Device for Intracranial Stroke Treatment
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Solution Overview
Problem
Current stroke treatment methods, such as stent placement and thrombolytic therapies, face challenges in achieving high recanalization rates without increasing the risk of hemorrhagic complications, and existing stents are not suitable for small intracranial vessels due to stiffness and deployment issues.
Innovation Solution
A tethered basket-like system is used in conjunction with a microcatheter to capture and remove emboli, featuring a mesh capturer that deploys distal to an embolus and advances proximally to contain it, allowing for safe removal without causing distal complications, and a self-expanding stent design that is flexible and can be delivered through a microcatheter for precise placement in small vessels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If stent placement is used to achieve recanalization, then recanalization rate is improved, but risk of hemorrhagic complications increases
Solution Approach 1:
The device segments the embolus capture function from the stent support function. The basket component captures and removes the embolus, while the stent component provides vascular support, allowing each component to optimize its specific function without compromising the other
Solution Approach 2:
The embolus is extracted from the vasculature using the basket mechanism before stent deployment. This removal of the harmful embolic material precedes the stent placement, reducing the risk of hemorrhagic transformation by eliminating the source of potential bleeding complications
2Strength
If traditional stents are used for intracranial vessels, then vessel support is improved, but deliverability to small vessels deteriorates due to stiffness
Solution Approach 1:
The stent transitions from a compressed, flexible state during delivery through the microcatheter to an expanded, rigid state after deployment. This dynamic transformation allows the stent to navigate small intracranial vessels in its compressed form and provide adequate radial support once expanded at the target site
Solution Approach 2:
The stent is nested within the microcatheter in a compressed configuration, allowing it to pass through small vessels. Upon deployment, the stent expands outward from the microcatheter, providing vessel support while maintaining the ability to access distal intracranial locations
3Productivity
If aggressive revascularization is performed, then recanalization rate is improved, but risk of distal embolization increases
Solution Approach 1:
The basket is deployed distal to the embolus before attempting recanalization maneuvers. This preliminary positioning creates a protective barrier that captures any embolic fragments generated during subsequent thrombolytic or mechanical interventions, preventing their distal migration
Solution Approach 2:
The basket acts as an intermediary barrier between the recanalization procedure and the distal vasculature. It intercepts and retains embolic particles that may be dislodged during aggressive revascularization attempts, allowing safe manipulation of the embolus
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system achieves immediate 50% lumen patency by removing emboli and filters potential distal migration of embolus particles, reducing the risk of further complications and enabling effective reperfusion without damaging the vasculature, while the self-expanding stent provides sufficient radial force for vessel conformity and is compatible with embolic agents.
Implementation Method 1
a self-expanding stent design that is flexible and can be delivered through a microcatheter for precise placement in small vessels
Data Source
AI summary
Systems for treatment of ischemic stroke can include tethered baskets. A basket can be tethered to a pusher or elongate member. A temporary reperfusion device or temporary capture device also can be tethered to the pusher or elongate member.